The Genes-to-Systems Breast Cancer (G2SBC) Database is a bioinformatics resource that collects and integrates data about genes, transcripts and proteins which have been reported in literature to be altered in breast cancer cells. Moreover, the resource includes a section dedicated to mathematical models related to cancerogenesis, tumour growth and tumour response to treatments.

The G2SBC Database is a multilevel resource dedicated to the molecular and systems biology of breast cancer, including both the building-blocks level (genes, transcripts and proteins) and the systems level (molecular and cellular systems, cell populations).

Taking advantage from the multilevel approach and from a series of tools for the analysis of the database content, the G2SBC Database enables predictions which may induce new experiments.

• Molecular components: literature derived evidences of molecular alterations in breast cancer, function and spatial localisation concerning genes, transcripts and proteins
• Molecular systems:pathways and protein-protein interaction network properties
• Cellular Systems: breast cancer types, mathematical models of cancer and cell cycle

• Blast vs G2SBC Database
• Gene-annotation enrichment analysis
• Neighbourhood density and hubs
• Ontologies
• Shortests paths
• SNP structural modelling

• Cellcycle & breast cancer: you will retreive the breast cancer genes involved in cell cycle control and simulate the associated mathematical models
• Mathematical models related to cancerogenesis, tumour growth and response to treatments