Gene: GJC1

official authority: GJC1, gap junction protein, gamma 1, 45kDa

• Synonyms: CX45; DKFZp686P0738; GJA7
• Other Designations: connexin 45; gap junction protein, alpha 7, 45kDa
• Description: gap junction protein, gamma 1, 45kDa
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 608655
  
• title:Gap junction protein, gamma 1, 45kDa;
• tissue expression: blood; bone; brain; connective tissue; embryonic tissue; eye; kidney; liver; lung; mammary gland; muscle; ovary; pancreas; placenta; prostate; skin; testis; uterus; breast (mammary gland) tumor; chondrosarcoma; germ cell tumor; kidney tumor; leukemia; liver tumor; non-neoplasia; normal; ovarian tumor; primitive neuroectodermal tumor of the CNS; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; embryoid body; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_001080383.1	NP_001073852.1	P36383	---
NC_000017.10	NM_005497.3	NP_005488.2	P36383	---

Gene Expression Data

• genes highly correlated to GJC1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: CXG1_HUMAN

• Description: Short=Cx45;
• Length: 396 aa
• Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
• Location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

InterPro domains

• Connexins (IPR000500)
• Gap junction alpha-6 protein (Cx45) (IPR002265)
• Gap junction protein, cysteine-rich domain (IPR019570)
• Connexin, conserved site (IPR017990)
• Connexin, N-terminal (IPR013092)
• Connexin region (IPR017991)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Gap junction trafficking and regulation (Reactome)

• Synaptic Transmission (Reactome)

• Synthesis of Cx45 (Reactome)

Gene Ontology

• Functions
  • protein binding (GO:0005515)
• Processes
  • vasculogenesis (GO:0001570)
  • transport (GO:0006810)
  • muscle contraction (GO:0006936)
  • cell-cell junction assembly (GO:0007043)
  • synaptic transmission (GO:0007268)
  • visual perception (GO:0007601)
  • cell development (GO:0048468)
  • cardiac muscle tissue development (GO:0048738)
• Components
  • plasma membrane (GO:0005886)
  • connexon complex (GO:0005922)
  • integral to membrane (GO:0016021)
  • cell junction (GO:0030054)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
GJA7	TJP1	Invitro	Laing JG et al.	12064590

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources