Gene: NR1H3

official authority: NR1H3, nuclear receptor subfamily 1, group H, member 3

• Synonyms: CHOP; LXR-a; LXRA; RLD-1; TLS/CHOP
• Other Designations: liver X receptor alpha; liver X receptor, alpha; liver X receptor-alpha
• Description: nuclear receptor subfamily 1, group H, member 3
• Type: protein-coding
• Chromosome: 11
• Organism: Homo sapiens
• Omim: 602423
  
• title:Nuclear receptor subfamily 1, group H, member 3;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; muscle; ovary; pancreas; parathyroid; placenta; prostate; salivary gland; spleen; stomach; testis; thymus; thyroid; tonsil; trachea; uterus; vascular; adrenal tumor; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; uterine tumor; embryoid body; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000011.9	NM_001130101.1	NP_001123573.1	Q13133	1UHL
NC_000011.9	NM_001130102.1	NP_001123574.1	Q8IW13	---
NC_000011.9	NM_005693.2	NP_005684.2	A8K3J9	---

Gene Expression Data

• genes highly correlated to NR1H3 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: NR1H3_HUMAN

• Description: AltName: Full=Nuclear receptor subfamily 1 group H member 3;
• Length: 447 aa
• Function: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis.
• Location: Nucleus (Potential).

InterPro domains

• Nuclear hormone receptor, ligand-binding (IPR008946)
• Nuclear hormone receptor, ligand-binding, core (IPR000536)
• Steroid hormone receptor (IPR001723)
• Thyroid hormone receptor (IPR001728)
• Zinc finger, nuclear hormone receptor-type (IPR001628)
• Zinc finger, NHR/GATA-type (IPR013088)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• PPAR signaling pathway (KEGG map) (KEGG ontology)

• Gene Expression (Reactome)

Gene Ontology

• Functions
  • transcription factor activity (GO:0003700)
  • steroid hormone receptor activity (GO:0003707)
  • transcription coactivator activity (GO:0003713)
  • thyroid hormone receptor activity (GO:0004887)
  • protein binding (GO:0005515)
  • zinc ion binding (GO:0008270)
  • sequence-specific DNA binding (GO:0043565)
  • metal ion binding (GO:0046872)
• Processes
  • transcription (GO:0006350)
  • regulation of transcription, DNA-dependent (GO:0006355)
  • positive regulation of specific transcription from RNA polymerase II promoter (GO:0010552)
  • negative regulation of foam cell differentiation (GO:0010745)
  • positive regulation of triglyceride biosynthetic process (GO:0010867)
  • positive regulation of cholesterol efflux (GO:0010875)
  • negative regulation of cholesterol storage (GO:0010887)
  • positive regulation of cellular protein metabolic process (GO:0032270)
  • negative regulation of lipid transport (GO:0032369)
  • positive regulation of fatty acid biosynthetic process (GO:0045723)
  • negative regulation of pinocytosis (GO:0048550)
  • positive regulation of lipoprotein lipase activity (GO:0051006)
• Components
  • nucleus (GO:0005634)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
PPARA	NR1H3	Invitro	Miyata KS et al.	8621574
PPARA	NR1H3	Two-hybrid	Miyata KS et al.	8621574
NRIP1	NR1H3	Invitro	Miyata KS et al.	10022764
NR0B2	NR1H3	Invivo	Brendel C et al.	12198243
RARA	NR1H3	Invitro	Miyata KS et al.	10022764
EDF1	NR1H3	Invitro	Brendel C et al.	12040021
PPARA	NR1H3	Affinity Capture-MS	Rual JF et al.	16189514
EDF1	NR1H3	Affinity Capture-MS	Rual JF et al.	16189514
RARA	NR1H3	Affinity Capture-MS	Rual JF et al.	16189514
NRIP1	NR1H3	Affinity Capture-MS	Rual JF et al.	16189514
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

---

Note: data printed here are integrated from public resources