Gene: CES1

official authority: CES1, carboxylesterase 1 (monocyte/macrophage serine esterase 1)

• Synonyms: ACAT; CEH; CES2; HMSE; HMSE1; MGC117365; PCE-1; SES1; TGH
• Other Designations: acyl coenzyme A:cholesterol acyltransferase; carboxylesterase 1; carboxylesterase 2 (liver); cholesteryl ester hydrolase; egasyn; liver carboxylesterase; triacylglycerol hydrolase
• Description: carboxylesterase 1 (monocyte/macrophage serine esterase 1)
• Type: protein-coding
• Chromosome: 16
• Organism: Homo sapiens
• Omim: 114835
  
• title:Carboxylesterase 1 (monocyte/macrophage serine esterase 1);
• tissue expression: adipose tissue; adrenal gland; blood; bone; brain; connective tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; mammary gland; mouth; muscle; ovary; pancreas; pharynx; placenta; prostate; spleen; stomach; testis; thymus; trachea; uterus; breast (mammary gland) tumor; chondrosarcoma; esophageal tumor; gastrointestinal tumor; head and neck tumor; liver tumor; lung tumor; non-neoplasia; normal; pancreatic tumor; prostate cancer; soft tissue/muscle tissue tumor; fetus; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Invasive Lobular Carcinoma vs Invasive Ductal Carcinoma	---	cDNA Microarray	---	10963602
Down	---	F	---	Normal Fibroadenoma vs Invasive Ductal Carcinoma	---	cDNA Microarray	---	10963602

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000016.9	NM_001025194.1	NP_001020365.1	P23141	1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR
NC_000016.9	NM_001025195.1	NP_001020366.1	P23141	1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR
NC_000016.9	NM_001266.4	NP_001257.4	P23141	1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR

Gene Expression Data

• genes highly correlated to CES1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: EST1_HUMAN

• Description: Flags: Precursor;
• Length: 567 aa
• Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester.
• Location: Endoplasmic reticulum lumen.

InterPro domains

• Carboxylesterase, type B (IPR002018)
• Carboxylesterase type B, active site (IPR019826)
• Carboxylesterase type B, conserved site (IPR019819)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Drug metabolism - other enzymes (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • carboxylesterase activity (GO:0004091)
  • hydrolase activity (GO:0016787)
• Processes
  • metabolic process (GO:0008152)
  • response to toxin (GO:0009636)
• Components
  • endoplasmic reticulum (GO:0005783)
  • endoplasmic reticulum lumen (GO:0005788)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
CES1	GUSB	Invitro	Islam MR et al.	10562416
CES1	GUSB	Invivo	Islam MR et al.	10562416
CES1	CES1	Invitro	Bencharit S et al.	12679808
CES1	CES1	Affinity Capture-MS	Rual JF et al.	16189514
CES1	GUSB	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

Drugs

Drug	Regulation	Cell	Method	Pubmed ID
Cerivastatin	Expression Upregulation	MDA-MB-231-Human	cDNA Microarray	12531431

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Note: data printed here are integrated from public resources