Gene: NES

official authority: NES, nestin

• Synonyms: FLJ21841; Nbla00170
• Other Designations: OTTHUMP00000032198
• Description: nestin
• Type: protein-coding
• Chromosome: 1
• Organism: Homo sapiens
• Omim: 600915
  
• title:Nestin;
• tissue expression: brain; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; lung; mammary gland; muscle; nerve; ovary; pancreas; placenta; prostate; skin; testis; thymus; thyroid; umbilical cord; uterus; vascular; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; germ cell tumor; glioma; kidney tumor; lung tumor; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000001.10	NM_006617.1	NP_006608.1	P48681	---

Gene Expression Data

• genes highly correlated to NES in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: NEST_HUMAN

• Description: RecName: Full=Nestin;
• Length: 1621 aa
• Function: May play a role in the trafficking and distribution of IF proteins and potentially other cellular factors to daughter cells during progenitor cell division (By similarity).
• Location:

InterPro domains

• Filament (IPR016044)
• Intermediate filament protein (IPR001664)
• Intermediate filament protein, conserved site (IPR018039)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • structural molecule activity (GO:0005198)
• Processes
  • central nervous system development (GO:0007417)
• Components
  • cytoskeleton (GO:0005856)
  • intermediate filament (GO:0005882)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
NES	CDK5	Invivo	Sahlgren CM et al.	12832492
NES	CDK5	Invitro	Sahlgren CM et al.	12832492
NES	CDK5R1	Invivo	Sahlgren CM et al.	12832492

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources