Gene: SUB1

official authority: SUB1, SUB1 homolog (S. cerevisiae)

• Synonyms: MGC102747; P15; PC4; p14
• Other Designations: activated RNA polymerase II transcription cofactor 4
• Description: SUB1 homolog (S. cerevisiae)
• Type: protein-coding
• Chromosome: 5
• Organism: Homo sapiens
• Omim: 600503
  
• title:SUB1 homolog (S. cerevisiae);
• tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000005.9	NM_006713.3	NP_006704.3	P53999	1PCF 2C62 2PHE

Gene Expression Data

• genes highly correlated to SUB1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: TCP4_HUMAN

• Description: AltName: Full=p14;
• Length: 127 aa
• Function: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
• Location: Nucleus.

InterPro domains

• Transcriptional coactivator p15 (IPR003173)
• ssDNA-binding transcriptional regulator (IPR009044)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • DNA binding (GO:0003677)
  • single-stranded DNA binding (GO:0003697)
  • transcription coactivator activity (GO:0003713)
  • protein binding (GO:0005515)
• Processes
  • transcription (GO:0006350)
  • regulation of transcription from RNA polymerase II promoter (GO:0006357)
• Components
  • nucleus (GO:0005634)
  • transcription factor complex (GO:0005667)
  • nucleolus (GO:0005730)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
HSF1	PC4	Invitro	Yuan CX et al.	11005381
PCNA	PC4	Two-hybrid	Yu P et al.	11313979
TAF1	PC4	Invitro	Malik S et al.	9482861
TBP	PC4	Invitro	Malik S et al.	9482861
PC4	HNF4A	Invivo	Guo H et al.	11741883
PC4	HNF4A	Invitro	Guo H et al.	11741883
CSTF2	PC4	Invivo	Calvo O et al.	11389848
CSTF2	PC4	Invitro	Calvo O et al.	11389848
CSTF2	PC4	Two-hybrid	Calvo O et al.	11389848
EP300	PC4	Invitro	Kumar BR et al.	11279157
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

---

Note: data printed here are integrated from public resources