Gene: WWP1

official authority: WWP1, WW domain containing E3 ubiquitin protein ligase 1

• Synonyms: AIP5; DKFZp434D2111; Tiul1; hSDRP1
• Other Designations: Nedd-4-like ubiquitin-protein ligase; TGIF-interacting ubiquitin ligase 1; atrophin-1 interacting protein 5
• Description: WW domain containing E3 ubiquitin protein ligase 1
• Type: protein-coding
• Chromosome: 8
• Organism: Homo sapiens
• Omim: 602307
  
• title:WW domain containing E3 ubiquitin protein ligase 1;
• tissue expression: adipose tissue; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; pharynx; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Estrogen receptor positive vs negative	---	cDNA Microarray	---	11562467

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000008.10	NM_007013.3	NP_008944.1	Q5YLC1	---

Gene Expression Data

• genes highly correlated to WWP1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: WWP1_HUMAN

• Description: Short=AIP5;
• Length: 922 aa
• Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
• Location:

InterPro domains

• C2 calcium-dependent membrane targeting (IPR000008)
• C2 membrane targeting protein (IPR018029)
• HECT (IPR000569)
• WW/Rsp5/WWP (IPR001202)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Ubiquitin mediated proteolysis (KEGG map) (KEGG ontology)
• Endocytosis (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • ubiquitin-protein ligase activity (GO:0004842)
  • protein binding (GO:0005515)
  • ligase activity (GO:0016874)
  • acid-amino acid ligase activity (GO:0016881)
• Processes
  • protein modification process (GO:0006464)
  • signal transduction (GO:0007165)
  • central nervous system development (GO:0007417)
  • negative regulation of transcription (GO:0016481)
  • protein ubiquitination (GO:0016567)
  • modification-dependent protein catabolic process (GO:0019941)
  • interspecies interaction between organisms (GO:0044419)
  • entry of virus into host cell (GO:0046718)
• Components
  • ubiquitin ligase complex (GO:0000151)
  • intracellular (GO:0005622)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
WWP1	KLF2	Invivo	Conkright MD et al.	11375995
WWP1	KLF2	Invitro	Conkright MD et al.	11375995
WWP1	KLF2	Two-hybrid	Conkright MD et al.	11375995
ATN1	WWP1	Two-hybrid	Wood JD et al.	9647693
WWP1	WBP1	Invivo	Pirozzi G et al.	9169421
WWP1	WBP1	Invitro	Pirozzi G et al.	9169421
WWP1	ZNF638	Two-hybrid	Rual JF et al.	16189514
CPSF6	WWP1	Two-hybrid	Rual JF et al.	16189514
EWSR1	WWP1	Two-hybrid	Rual JF et al.	16189514
DAZAP2	WWP1	Two-hybrid	Rual JF et al.	16189514
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources