Gene: RFFL

official authority: RFFL, ring finger and FYVE-like domain containing 1

• Synonyms: CARP2; RIFIFYLIN; RNF189; RNF34L
• Other Designations: FYVE-RING finger protein SAKURA; caspases-8 and -10-associated RING finger protein 2; fring; rififylin
• Description: ring finger and FYVE-like domain containing 1
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 609735
  
• title:Ring finger and FYVE-like domain containing 1;
• tissue expression: blood; bone; bone marrow; brain; connective tissue; ear; embryonic tissue; eye; heart; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; placenta; prostate; skin; spleen; testis; thymus; trachea; uterus; chondrosarcoma; colorectal tumor; germ cell tumor; glioma; head and neck tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_001017368.1	NP_001017368.1	Q8WZ73	1Y02
NC_000017.10	NM_057178.3	NP_476519.1	Q8WZ73	1Y02

Gene Expression Data

• genes highly correlated to RFFL in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: RFFL_HUMAN

• Description: AltName: Full=RING finger protein 34-like;
• Length: 363 aa
• Function: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
• Location: Cytoplasm. Membrane; Peripheral membrane protein.

InterPro domains

• Zinc finger, RING-type (IPR001841)
• Zinc finger, RING-type, conserved site (IPR017907)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • protein binding (GO:0005515)
  • zinc ion binding (GO:0008270)
  • ligase activity (GO:0016874)
  • metal ion binding (GO:0046872)
• Processes
  • intracellular protein transport (GO:0006886)
  • apoptosis (GO:0006915)
  • modification-dependent protein catabolic process (GO:0019941)
• Components
  • cytoplasm (GO:0005737)
  • membrane (GO:0016020)
  • cytoplasmic membrane-bounded vesicle (GO:0016023)

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Note: data printed here are integrated from public resources