Gene: AAMP

official authority: AAMP, angio-associated, migratory cell protein

• Synonyms: -
• Other Designations: -
• Description: angio-associated, migratory cell protein
• Type: protein-coding
• Chromosome: 2
• Organism: Homo sapiens
• Omim: 603488
  
• title:Angio-associated, migratory cell protein;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	F	---	BRCA1 mutation positive, Sporadic vs BRCA2 mutation positive	---	cDNA Microarray	---	11207349

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000002.11	NM_001087.3	NP_001078.2	Q13685	---

Gene Expression Data

• genes highly correlated to AAMP in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: AAMP_HUMAN

• Description: RecName: Full=Angio-associated migratory cell protein;
• Length: 434 aa
• Function: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.
• Location: Cell membrane. Cytoplasm.

InterPro domains

• WD40/YVTN repeat-like (IPR015943)
• WD40 repeat (IPR001680)
• WD40 repeat 2 (IPR019782)
• WD40 repeat, conserved site (IPR019775)
• WD40 repeat, region (IPR017986)
• WD40 repeat, subgroup (IPR019781)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • heparin binding (GO:0008201)
• Processes
  • angiogenesis (GO:0001525)
  • multicellular organismal development (GO:0007275)
  • positive regulation of endothelial cell migration (GO:0010595)
  • smooth muscle cell migration (GO:0014909)
  • cell differentiation (GO:0030154)
• Components
  • cytoplasm (GO:0005737)
  • plasma membrane (GO:0005886)
  • cell surface (GO:0009986)

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Note: data printed here are integrated from public resources