Gene: CD55

official authority: CD55, CD55 molecule, decay accelerating factor for complement (Cromer blood group)

• Synonyms: CR; CROM; DAF; TC
• Other Designations: CD55 antigen; decay accelerating factor for complement
• Description: CD55 molecule, decay accelerating factor for complement (Cromer blood group)
• Type: protein-coding
• Chromosome: 1
• Organism: Homo sapiens
• Omim: 125240
  
• title:CD55 molecule, decay accelerating factor for complement (Cromer blood group);
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; muscle; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000001.10	NM_000574.3	NP_000565.1	B1AP14	---
NC_000001.10	NM_001114752.1	NP_001108224.1	P08174	1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH

Gene Expression Data

• genes highly correlated to CD55 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: DAF_HUMAN

• Description: Flags: Precursor;
• Length: 381 aa
• Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
• Location: Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.

InterPro domains

• Complement control module (IPR016060)
• Sushi/SCR/CCP (IPR000436)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Complement and coagulation cascades (KEGG map) (KEGG ontology)
• Hematopoietic cell lineage (KEGG map) (KEGG ontology)
• Viral myocarditis (KEGG map) (KEGG ontology)

Gene Ontology

• Processes
  • complement activation, classical pathway (GO:0006958)
  • elevation of cytosolic calcium ion concentration (GO:0007204)
  • innate immune response (GO:0045087)
  • respiratory burst (GO:0045730)
• Components
  • soluble fraction (GO:0005625)
  • plasma membrane (GO:0005886)
  • integral to plasma membrane (GO:0005887)
  • anchored to membrane (GO:0031225)
  • membrane raft (GO:0045121)

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Note: data printed here are integrated from public resources