Gene: DLAT
official authority: DLAT, dihydrolipoamide S-acetyltransferase
- Synonyms: DLTA; PDC-E2; PDCE2
- Other Designations: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; E2 component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit
- Description: dihydrolipoamide S-acetyltransferase
- Type: protein-coding
- Chromosome: 11
- Organism: Homo sapiens
- Omim: 608770
- title:Dihydrolipoamide S-acetyltransferase;
- tissue expression: ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;
Molecular alterations reported in literature
Gene products
| genomic | RNA | protein | Uniprot accession | PDB Structure |
| NC_000011.9 | NM_001931.3 | NP_001922.2 | P10515 | 1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL |
Gene Expression Data
- genes highly correlated to DLAT in a primary tumour dataset
- Differential Gene Expression
- Gene Expression Atlas
Interacting miRNA
- view miRNA list
Protein: ODP2_HUMAN
- Description: Flags: Precursor;
- Length: 647 aa
- Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
- Location: Mitochondrion matrix.
InterPro domains
- 2-oxo acid dehydrogenase, lipoyl-binding site (IPR003016)
- 2-oxoacid dehydrogenase acyltransferase, catalytic domain (IPR001078)
- Dihydrolipoamide acetyltransferase, long form (IPR006257)
- Biotin/lipoyl attachment (IPR000089)
- E3 binding (IPR004167)
SNPs and Protein Structural Models
- view SNPs list and use modelling tool
Human Protein Atlas stained tissues
- Protein expression in breast cancer tissues
- show related stained tissue images
Pathways
- Glycolysis / Gluconeogenesis (KEGG map) (KEGG ontology)
- Citrate cycle (TCA cycle) (KEGG map) (KEGG ontology)
- Pyruvate metabolism (KEGG map) (KEGG ontology)
- Metabolic pathways (KEGG map) (KEGG ontology)
Diabetes pathways (Reactome)
Integration of energy metabolism (Reactome)
Metabolism of carbohydrates (Reactome)
Pyruvate metabolism and TCA cycle (Reactome)
Gene Ontology
BioGrid interactions
| Interactant A | Interactant B | experiment | source | Pubmed ID |
| PDK1 | DLAT | Invitro | Tuganova A et al. | 11978179 |
| PDK2 | DLAT | Invitro | Hiromasa Y et al. | 12816949 |
| PDK3 | DLAT | Invitro | Tuganova A et al. | 11978179 |
| PDK4 | DLAT | Invitro | Tuganova A et al. | 11978179 |
| DLAT | PDK2 | Affinity Capture-MS | Rual JF et al. | 16189514 |
| DLAT | PDK1 | Affinity Capture-MS | Rual JF et al. | 16189514 |
| DLAT | PDK3 | Affinity Capture-MS | Rual JF et al. | 16189514 |
| DLAT | PDHX | Affinity Capture-MS | Rual JF et al. | 16189514 |
| DLAT | PDHA1 | Affinity Capture-MS | Rual JF et al. | 16189514 |
| DLAT | PDHB | Affinity Capture-MS | Rual JF et al. | 16189514 |
| view the complete list | ||||
Note: data printed here are integrated from public resources