Gene: EEF2

official authority: EEF2, eukaryotic translation elongation factor 2

• Synonyms: EEF-2; EF2
• Other Designations: polypeptidyl-tRNA translocase
• Description: eukaryotic translation elongation factor 2
• Type: protein-coding
• Chromosome: 19
• Organism: Homo sapiens
• Omim: 130610
  
• title:Eukaryotic translation elongation factor 2;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; tonsil; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Grade 1(2) vs 3	---	cDNA microarray	---	11823860
Up	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000019.9	NM_001961.3	NP_001952.1	B2RMP5	---

Gene Expression Data

• genes highly correlated to EEF2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: EF2_HUMAN

• Description: Short=EF-2;
• Length: 858 aa
• Function: This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.
• Location: Cytoplasm.

InterPro domains

• Protein synthesis factor, GTP-binding (IPR000795)
• Ribosomal protein S5 domain 2-type fold (IPR014721)
• Small GTP-binding protein (IPR005225)
• Translation elongation factor EFG/EF2, C-terminal (IPR000640)
• Translation elongation factor EFG/EF2, domain IV (IPR005517)
• Translation elongation factor EFTu/EF1A, domain 2 (IPR004161)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Gene Expression (Reactome)

• Metabolism of proteins (Reactome)

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • translation elongation factor activity (GO:0003746)
  • GTPase activity (GO:0003924)
  • protein binding (GO:0005515)
  • GTP binding (GO:0005525)
• Processes
  • translational elongation (GO:0006414)
• Components
  • cytoplasm (GO:0005737)
  • ribonucleoprotein complex (GO:0030529)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
TP53	EEF2	Invivo	Yin X et al.	12891704

Show common annotations on gene first neighborhood in the protein-protein interaction network

Drugs

Drug	Regulation	Cell	Method	Pubmed ID
17beta-estradiol	Expression Downregulation	MCF-7 - Human	Oligonucleotide microarray	12959972

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Note: data printed here are integrated from public resources