Gene: EPHB4

official authority: EPHB4, EPH receptor B4

• Synonyms: HTK; MYK1; TYRO11
• Other Designations: ephrin receptor EphB4; hepatoma transmembrane kinase; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3
• Description: EPH receptor B4
• Type: protein-coding
• Chromosome: 7
• Organism: Homo sapiens
• Omim: 600011
  
• title:EPH receptor B4;
• tissue expression: adrenal gland; ascites; bone; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; mammary gland; mouth; muscle; nerve; ovary; pancreas; pharynx; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thyroid; trachea; uterus; vascular; adrenal tumor; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; liver tumor; lung tumor; non-neoplasia; normal; ovarian tumor; pancreatic tumor; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA Microarray	---	11207349
Down	---	F	---	BRCA1 mutation positive, Sporadic vs BRCA2 mutation positive	---	cDNA Microarray	---	11207350
Down	---	F	---	Lymph node positive vs negative	---	cDNA Microarray Real Time PCR	---	11673828
Up	---	F	---	Estrogen receptor positive vs negative	---	cDNA Microarray, Real Time PCR	---	11673828
Up	---	F	20	Normal vs Invasive Ductal Carcinoma Invasive Lobular Carcinoma	---	cDNA Microarray Real Time PCR	---	11673828
Up	---	F	---	Progesterone receptor positive vs negative	---	cDNA Microarray Real Time PCR	---	11673828

• Protein Altered Localization - Clinical data

Altered site	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Cytoplasm	F	---	Normal vs Invasive Metastatic	---	Immunohistochemistry	---	15029258

• Protein Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Estrogen receptor positive vs negative	---	Immunohistochemistry	---	12168060
Down	---	F	---	Normal vs Ductal Carcinoma in situ Invasive Ductal Carcinoma Invasive Lobular Carcinoma Invasive Mucinous Carcinoma	---	Immunohistochemistry	---	12168060

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000007.13	NM_004444.4	NP_004435.3	P54760	2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1

Gene Expression Data

• genes highly correlated to EPHB4 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: EPHB4_HUMAN

• Description: Flags: Precursor;
• Length: 987 aa
• Function: Receptor for members of the ephrin-B family. Binds to ephrin-B2. May have a role in events mediating differentiation and development.
• Location: Membrane; Single-pass type I membrane protein.

InterPro domains

• EGF-like region, conserved site (IPR013032)
• Ephrin receptor, ligand binding (IPR001090)
• Fibronectin, type III-like fold (IPR008957)
• Fibronectin, type III (IPR003961)
• Protein kinase, core (IPR000719)
• Protein kinase, ATP binding site (IPR017441)
• Sterile alpha motif SAM (IPR001660)
• Sterile alpha motif-type (IPR013761)
• Tyrosine protein kinase (IPR001245)
• Tyrosine protein kinase, active site (IPR008266)
• Tyrosine-protein kinase, ephrin receptor (IPR016257)
• Receptor tyrosine kinase, class V, conserved site (IPR001426)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Axon guidance (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • receptor activity (GO:0004872)
  • ephrin receptor activity (GO:0005003)
  • ATP binding (GO:0005524)
  • transferase activity (GO:0016740)
• Processes
  • protein amino acid phosphorylation (GO:0006468)
  • transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)
  • cell proliferation (GO:0008283)
  • organ morphogenesis (GO:0009887)
  • regulation of angiogenesis (GO:0045765)
• Components
  • integral to plasma membrane (GO:0005887)
  • cell surface (GO:0009986)
  • membrane (GO:0016020)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
EFNB2	EPHB4	Invivo	Suenobu S et al.	12051776
EFNB2	EPHB4	Invivo	Nikolova Z et al.	9718367

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources