Gene: ETFB

official authority: ETFB, electron-transfer-flavoprotein, beta polypeptide

• Synonyms: FP585; MADD
• Other Designations: electron transfer flavoprotein beta subunit; electron transfer flavoprotein beta-subunit; electron transfer flavoprotein, beta polypeptide; electron-transferring-flavoprotein, beta polypeptide
• Description: electron-transfer-flavoprotein, beta polypeptide
• Type: protein-coding
• Chromosome: 19
• Organism: Homo sapiens
• Omim: 130410
  
• title:Electron-transfer-flavoprotein, beta polypeptide;
• tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; eye; heart; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; muscle; ovary; pancreas; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; tonsil; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	ErbB2 positive vs negative	---	cDNA Microarray	---	10963602
Down	---	F	---	Normal Fibroadenoma vs Invasive Ductal Carcinoma Invasive Lobular Carcinoma	---	cDNA Microarray	---	10963602
Up	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000019.9	NM_001014763.1	NP_001014763.1	P38117	1EFV 1T9G 2A1T 2A1U
NC_000019.9	NM_001985.2	NP_001976.1	P38117	1EFV 1T9G 2A1T 2A1U

Gene Expression Data

• genes highly correlated to ETFB in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: ETFB_HUMAN

• Description: Short=Beta-ETF;
• Length: 255 aa
• Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
• Location: Mitochondrion matrix.

InterPro domains

• Electron transfer flavoprotein, alpha/beta-subunit, N-terminal (IPR014730)
• Electron transfer flavoprotein, beta subunit (IPR012255)
• Electron transfer flavoprotein, beta-subunit, core (IPR000049)
• Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Diabetes pathways (Reactome)

• Integration of energy metabolism (Reactome)

Gene Ontology

• Functions
  • electron carrier activity (GO:0009055)
• Processes
  • transport (GO:0006810)
  • electron transport chain (GO:0022900)
• Components
  • mitochondrion (GO:0005739)
  • mitochondrial matrix (GO:0005759)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
ETFA	ETFB	Invivo	White RA et al.	8617498

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources