Gene: KLRK1

official authority: KLRK1, killer cell lectin-like receptor subfamily K, member 1

• Synonyms: CD314; D12S2489E; FLJ17759; FLJ75772; KLR; NKG2-D; NKG2D
• Other Designations: NK cell receptor D; NKG2-D type II integral membrane protein
• Description: killer cell lectin-like receptor subfamily K, member 1
• Type: protein-coding
• Chromosome: 12
• Organism: Homo sapiens
• Omim: 611817
  
• title:Killer cell lectin-like receptor subfamily K, member 1;
• tissue expression: ascites; blood; brain; cervix; connective tissue; kidney; liver; lung; lymph; lymph node; muscle; ovary; pharynx; placenta; skin; spleen; stomach; thymus; trachea; uterus; cervical tumor; chondrosarcoma; gastrointestinal tumor; germ cell tumor; leukemia; liver tumor; lymphoma; normal; ovarian tumor; skin tumor; soft tissue/muscle tissue tumor; fetus; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000012.11	NM_007360.2	NP_031386.2	P26718	1HYR 1KCG 1MPU

Gene Expression Data

• genes highly correlated to KLRK1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: NKG2D_HUMAN

• Description: AltName: CD_antigen=CD314;
• Length: 216 aa
• Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
• Location: Membrane; Single-pass type II membrane protein.

InterPro domains

• Type II antifreeze protein (IPR002353)
• C-type lectin (IPR001304)
• C-type lectin-like (IPR016186)
• C-type lectin, conserved site (IPR018378)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Natural killer cell mediated cytotoxicity (KEGG map) (KEGG ontology)

• Signaling in Immune system (Reactome)

Gene Ontology

• Functions
  • receptor activity (GO:0004872)
  • protein binding (GO:0005515)
  • sugar binding (GO:0005529)
• Processes
  • signal transduction (GO:0007165)
  • natural killer cell activation (GO:0030101)
  • T cell costimulation (GO:0031295)
• Components
  • integral to plasma membrane (GO:0005887)
  • membrane (GO:0016020)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
KLRK1	MICB	Invitro	Holmes MA et al.	12133964
HCST	KLRK1	Invivo	Wu J et al.	10426994
HCST	KLRK1	Invitro	Wu J et al.	10426994

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources