Gene: SCAP

official authority: SCAP, SREBF chaperone

• Synonyms: KIAA0199
• Other Designations: SREBF chaperone protein; SREBP cleavage activating protein; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein
• Description: SREBF chaperone
• Type: protein-coding
• Chromosome: 3
• Organism: Homo sapiens
• Omim: 601510
  
• title:SREBF chaperone;
• tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; mouth; muscle; ovary; pancreas; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA Microarray	---	11207349

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000003.11	NM_012235.2	NP_036367.2	Q12770	---

Gene Expression Data

• genes highly correlated to SCAP in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: SCAP_HUMAN

• Description: Short=SCAP;
• Length: 1279 aa
• Function: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
• Location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi- pass membrane protein (By similarity). Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein (By similarity). Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity).

InterPro domains

• Sterol-sensing 5TM box (IPR000731)
• WD40/YVTN repeat-like (IPR015943)
• WD40 repeat (IPR001680)
• WD40 repeat 2 (IPR019782)
• WD40 repeat, conserved site (IPR019775)
• WD40 repeat, region (IPR017986)
• WD40 repeat, subgroup (IPR019781)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • unfolded protein binding (GO:0051082)
• Processes
  • lipid metabolic process (GO:0006629)
  • positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response (GO:0006994)
  • steroid metabolic process (GO:0008202)
  • cholesterol metabolic process (GO:0008203)
  • negative regulation of cholesterol biosynthetic process (GO:0045541)
  • positive regulation of low-density lipoprotein receptor biosynthetic process (GO:0045716)
• Components
  • Golgi membrane (GO:0000139)
  • endoplasmic reticulum (GO:0005783)
  • endoplasmic reticulum membrane (GO:0005789)
  • Golgi apparatus (GO:0005794)
  • ER to Golgi transport vesicle membrane (GO:0012507)
  • membrane (GO:0016020)
  • integral to membrane (GO:0016021)
  • cytoplasmic vesicle (GO:0031410)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
SCAP	SREBF2	Invivo	Yang T et al.	10896675
SCAP	SREBF2	Invitro	Yang T et al.	10896675
INSIG1	SCAP	Invivo	Dobrosotskaya IY et al.	12842885
INSIG1	SCAP	Invivo	Yang T et al.	12202038
INSIG1	SCAP	Invivo	Yabe D et al.	12482938
INSIG1	SCAP	Invitro	Dobrosotskaya IY et al.	12842885
INSIG1	SCAP	Invitro	Yang T et al.	12202038
INSIG1	SCAP	Invitro	Yabe D et al.	12482938
INSIG1	SCAP	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources