Gene: WDTC1

official authority: WDTC1, WD and tetratricopeptide repeats 1

• Synonyms: ADP; KIAA1037
• Other Designations: OTTHUMP00000004473; adipose homolog
• Description: WD and tetratricopeptide repeats 1
• Type: protein-coding
• Chromosome: 1
• Organism: Homo sapiens
• Omim: 0
  
• title:WD and tetratricopeptide repeats 1;
• tissue expression: adipose tissue; ascites; blood; bone; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; pituitary gland; placenta; prostate; salivary gland; skin; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000001.10	NM_015023.3	NP_055838.2	Q5SSC5	---

Gene Expression Data

• genes highly correlated to WDTC1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: WDTC1_HUMAN

• Description: RecName: Full=WD and tetratricopeptide repeats protein 1;
• Length: 677 aa
• Function:
• Location:

InterPro domains

• Tetratricopeptide region (IPR013026)
• WD40/YVTN repeat-like (IPR015943)
• WD40 repeat (IPR001680)
• WD40 repeat 2 (IPR019782)
• WD40 repeat, conserved site (IPR019775)
• WD40 repeat, region (IPR017986)
• WD40 repeat, subgroup (IPR019781)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • enzyme inhibitor activity (GO:0004857)
  • histone binding (GO:0042393)
  • histone deacetylase binding (GO:0042826)
• Processes
  • in utero embryonic development (GO:0001701)
  • glucose metabolic process (GO:0006006)
  • regulation of cell size (GO:0008361)
  • negative regulation of specific transcription from RNA polymerase II promoter (GO:0010553)
  • cellular response to insulin stimulus (GO:0032869)
  • multicellular organism growth (GO:0035264)
  • negative regulation of fatty acid biosynthetic process (GO:0045717)
  • cellular chemical homeostasis (GO:0055082)
• Components
  • nucleus (GO:0005634)
  • cytosol (GO:0005829)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
VCL	WDTC1	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources