Gene: TNRC6B

official authority: TNRC6B, trinucleotide repeat containing 6B

• Synonyms: KIAA1093
• Other Designations: OTTHUMP00000028832
• Description: trinucleotide repeat containing 6B
• Type: protein-coding
• Chromosome: 22
• Organism: Homo sapiens
• Omim: 610740
  
• title:Trinucleotide repeat containing 6B;
• tissue expression: adipose tissue; adrenal gland; blood; bone; bone marrow; brain; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pharynx; pituitary gland; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; uterus; vascular; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; embryoid body; blastocyst; fetus; infant; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000022.10	NM_001024843.1	NP_001020014.1	B0QY73	---
NC_000022.10	NM_015088.2	NP_055903.2	Q9UPQ9	---

Gene Expression Data

• genes highly correlated to TNRC6B in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: TNR6B_HUMAN

• Description: RecName: Full=Trinucleotide repeat-containing gene 6B protein;
• Length: 1833 aa
• Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.
• Location: Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

InterPro domains

• Nucleotide-binding, alpha-beta plait (IPR012677)
• Argonaute hook (IPR019486)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • RNA binding (GO:0003723)
• Processes
  • regulation of translation (GO:0006417)
  • gene silencing by RNA (GO:0031047)
• Components
  • cytoplasmic mRNA processing body (GO:0000932)
  • nucleus (GO:0005634)
  • cytoplasm (GO:0005737)
  • Golgi apparatus (GO:0005794)
  • centrosome (GO:0005813)

---

Note: data printed here are integrated from public resources