Gene: RHOBTB2

official authority: RHOBTB2, Rho-related BTB domain containing 2

• Synonyms: DBC2; KIAA0717
• Other Designations: OTTHUMP00000123494; deleted in breast cancer 2
• Description: Rho-related BTB domain containing 2
• Type: protein-coding
• Chromosome: 8
• Organism: Homo sapiens
• Omim: 607352
  
• title:Rho-related BTB domain containing 2;
• tissue expression: ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; tonsil; trachea; uterus; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; leukemia; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; fetus; infant; adult;

Molecular alterations reported in literature

• DNA Deletion - Clinical data

Contig number	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
1231775-1252021	F	---	Normal vs Pre-invasive Invasive	---	Reverse transcription PCR	3	12370419

• DNA Transition - Clinical data

Contig number	Nucleotide change	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
1238966	G --> A	F	---	Normal vs Pre-invasive Invasive	---	Denaturing High Performance Liquid Chromatography Single Strand Conformation Polymorphism	---	12370419

• DNA Transversion - Cell Line data

Contig number	Nucleotide change	Cell line	Methods	Link to Pubmed
1239174	A --> C	BT483 - Human	Denaturing High Performance Liquid Chromatography Single Strand Conformation Polymorphism	12370419

• RNA Expression - Cell Line data

Expression	Fold	Cell line	Methods	Link to Pubmed
Down	---	SK-BR-3 - Human vs T-47D - Human	Reverse transcription PCR	12370419

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Normal vs Pre-invasive Invasive	---	Reverse transcription PCR	---	12370419

• Protein Aminoacid Change - Cell Line data

Aminoacid change type	Site	Aminoacid change	Cell line	Methods	Link to Pubmed
SNP	1078290676	D -> A	BT483 - Human	---	12370419

• Protein Aminoacid Change - Clinical data

Aminoacid change type	Site	Aminoacid change	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
SNP	299	D --> N	F	---	Normal vs Pre-invasive Invasive	---	Protein Truncation Test	---	12370419

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000008.10	NM_015178.2	NP_055993.2	Q9BYZ6	---

Gene Expression Data

• genes highly correlated to RHOBTB2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: RHBT2_HUMAN

• Description: AltName: Full=p83;
• Length: 727 aa
• Function:
• Location:

InterPro domains

• BTB/POZ-like (IPR000210)
• BTB/POZ fold (IPR011333)
• BTB/POZ (IPR013069)
• Ras small GTPase, Rho type (IPR003578)
• Ras (IPR013753)
• Ras GTPase (IPR001806)
• Small GTP-binding protein (IPR005225)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Ubiquitin mediated proteolysis (KEGG map) (KEGG ontology)

• Signaling by Rho GTPases (Reactome)

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • protein binding (GO:0005515)
  • GTP binding (GO:0005525)
• Processes
  • small GTPase mediated signal transduction (GO:0007264)
• Components
  • intracellular (GO:0005622)

---

Note: data printed here are integrated from public resources