Gene: RICTOR

official authority: RICTOR, RPTOR independent companion of MTOR, complex 2

• Synonyms: DKFZp686B11164; KIAA1999; MGC39830; PIA; mAVO3
• Other Designations: TORC2-specific protein AVO3; pianissimo; rapamycin-insensitive companion of mTOR
• Description: RPTOR independent companion of MTOR, complex 2
• Type: protein-coding
• Chromosome: 5
• Organism: Homo sapiens
• Omim: 609022
  
• title:Rapamycin-insensitive companion of mTOR;
• tissue expression: adipose tissue; ascites; bladder; blood; bone; bone marrow; brain; cervix; embryonic tissue; esophagus; eye; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; muscle; nerve; ovary; pancreas; pharynx; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; uterus; vascular; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; leukemia; liver tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; skin tumor; uterine tumor; embryoid body; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000005.9	NM_152756.3	NP_689969.2	Q6R327	---

Gene Expression Data

• genes highly correlated to RICTOR in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: RICTR_HUMAN

• Description: RecName: Full=Rapamycin-insensitive companion of mTOR;
• Length: 1708 aa
• Function: Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
• Location:

InterPro domains

• Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal (IPR000651)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• mTOR signaling pathway (KEGG map) (KEGG ontology)

• Signalling by NGF (Reactome)

Gene Ontology

• Functions
  • guanyl-nucleotide exchange factor activity (GO:0005085)
  • protein binding (GO:0005515)
• Processes
  • embryonic development (GO:0009790)
  • positive regulation of actin filament polymerization (GO:0030838)
  • actin cytoskeleton reorganization (GO:0031532)
  • regulation of Rac GTPase activity (GO:0032314)
  • positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)
  • regulation of small GTPase mediated signal transduction (GO:0051056)
  • regulation of protein kinase B signaling cascade (GO:0051896)
• Components
  • intracellular (GO:0005622)
  • TORC2 complex (GO:0031932)

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Note: data printed here are integrated from public resources