Gene: GNB2

official authority: GNB2, guanine nucleotide binding protein (G protein), beta polypeptide 2

• Synonyms: -
• Other Designations: G protein, beta-2 subunit; OTTHUMP00000174601; OTTHUMP00000174602; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2; guanine nucleotide-binding protein, beta-2 subunit; signal-transducing guanine nucleotide-binding regulatory protein beta subunit; transducin beta chain 2
• Description: guanine nucleotide binding protein (G protein), beta polypeptide 2
• Type: protein-coding
• Chromosome: 7
• Organism: Homo sapiens
• Omim: 139390
  
• title:Guanine nucleotide binding protein (G protein), beta polypeptide 2;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; tonsil; uterus; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000007.13	NM_005273.3	NP_005264.2	P62879	---

Gene Expression Data

• genes highly correlated to GNB2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: GBB2_HUMAN

• Description: AltName: Full=G protein subunit beta-2;
• Length: 340 aa
• Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
• Location:

InterPro domains

• G-protein, beta subunit (IPR001632)
• Guanine nucleotide-binding protein, beta subunit (IPR016346)
• WD40/YVTN repeat-like (IPR015943)
• WD40 repeat (IPR001680)
• WD40 repeat 2 (IPR019782)
• WD40 repeat, conserved site (IPR019775)
• WD40 repeat, region (IPR017986)
• WD40 repeat, subgroup (IPR019781)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Chemokine signaling pathway (KEGG map) (KEGG ontology)

• Hemostasis (Reactome)

• Integration of energy metabolism (Reactome)

• Opioid Signalling (Reactome)

• Signaling by GPCR (Reactome)

Gene Ontology

• Functions
  • GTPase activity (GO:0003924)
  • signal transducer activity (GO:0004871)
  • calcium channel regulator activity (GO:0005246)
• Processes
  • signal transduction (GO:0007165)
  • G-protein coupled receptor protein signaling pathway (GO:0007186)
  • hormone-mediated signaling (GO:0009755)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
GNB2	GNG10	Invitro	Ray K et al.	7665596
GNB2	GNG7	Invivo	Ueda N et al.	8308009
FANCA	GNB2	Two-hybrid	Reuter TY et al.	14499622

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources