Gene: HCLS1

official authority: HCLS1, hematopoietic cell-specific Lyn substrate 1

• Synonyms: CTTNL; HS1
• Other Designations: cortactin-like
• Description: hematopoietic cell-specific Lyn substrate 1
• Type: protein-coding
• Chromosome: 3
• Organism: Homo sapiens
• Omim: 601306
  
• title:Hematopoietic cell-specific Lyn substrate 1;
• tissue expression: blood; bone; bone marrow; brain; cervix; connective tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; pharynx; placenta; prostate; spleen; stomach; testis; thymus; tonsil; trachea; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; soft tissue/muscle tissue tumor; uterine tumor; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA Microarray	---	11823860
Down	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA Microarray	---	11823860
Up	---	F	---	Grade 1(2) vs 3	---	cDNA Microarray	---	11823860
Up	---	F	---	Normal Fibroadenoma vs Invasive Ductal Carcinoma	---	cDNA Microarray	---	10963602
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA Microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000003.11	NM_005335.4	NP_005326.2	P14317	---

Gene Expression Data

• genes highly correlated to HCLS1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: HCLS1_HUMAN

• Description: AltName: Full=p75;
• Length: 486 aa
• Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
• Location: Membrane; Peripheral membrane protein (Probable). Cytoplasm (Probable). Mitochondrion (Probable).

InterPro domains

• Hs1/Cortactin (IPR003134)
• Neutrophil cytosol factor 2 (IPR000108)
• Src homology-3 domain (IPR001452)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Tight junction (KEGG map) (KEGG ontology)
• Pathogenic Escherichia coli infection (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • transcription factor activity (GO:0003700)
  • protein binding (GO:0005515)
  • SH3 domain binding (GO:0017124)
• Processes
  • regulation of transcription, DNA-dependent (GO:0006355)
  • intracellular signaling cascade (GO:0007242)
  • positive regulation of cell proliferation (GO:0008284)
  • response to hormone stimulus (GO:0009725)
  • erythrocyte differentiation (GO:0030218)
  • positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)
• Components
  • nucleus (GO:0005634)
  • DNA-directed RNA polymerase II, core complex (GO:0005665)
  • cytoplasm (GO:0005737)
  • mitochondrion (GO:0005739)
  • membrane (GO:0016020)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
HCLS1	CD79A	Invivo	Hata D et al.	7927516
HCLS1	LYN	Invivo	Yamanashi Y et al.	7682714
HCLS1	LYN	Invitro	Yamanashi Y et al.	7682714
HCLS1	CASP3	Invitro	Ruzzene M et al.	11988074
HCLS1	CASP3	Invitro	Chen YR et al.	11689006
HCLS1	MAP4K1	Invivo	Nagata Y et al.	10233887
HCLS1	ACTR2	Invitro	Uruno T et al.	12534372
HCLS1	SH2D4A	Two-hybrid	Rual JF et al.	16189514
CASP3	HCLS1	Affinity Capture-MS	Rual JF et al.	16189514
HCLS1	ACTR2	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources