Gene: IL6ST

official authority: IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor)

• Synonyms: CD130; CDw130; GP130; GP130-RAPS; IL6R-beta
• Other Designations: CD130 antigen; IL6ST nirs variant 3; OTTHUMP00000122545; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; interleukin 6 signal transducer; interleukin receptor beta chain; membrane glycoprotein gp130; oncostatin M receptor
• Description: interleukin 6 signal transducer (gp130, oncostatin M receptor)
• Type: protein-coding
• Chromosome: 5
• Organism: Homo sapiens
• Omim: 600694
  
• title:Interleukin 6 signal transducer (gp130, oncostatin M receptor);
• tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph node; mammary gland; muscle; nerve; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA Microarray	---	11823860
Up	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA Microarray	---	11823860
Up	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA Microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000005.9	NM_002184.2	NP_002175.2	P40189	1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH
NC_000005.9	NM_175767.1	NP_786943.1	P40189	1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH

Gene Expression Data

• genes highly correlated to IL6ST in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: IL6RB_HUMAN

• Description: Flags: Precursor;
• Length: 918 aa
• Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
• Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

InterPro domains

• Fibronectin, type III-like fold (IPR008957)
• Fibronectin, type III (IPR003961)
• Long hematopoietin receptor, gp130 family 2, conserved site (IPR003529)
• Immunoglobulin-like fold (IPR013783)
• Immunoglobulin C2-set-like, ligand-binding (IPR010457)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Cytokine-cytokine receptor interaction (KEGG map) (KEGG ontology)
• Jak-STAT signaling pathway (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • receptor activity (GO:0004872)
  • ciliary neurotrophic factor receptor activity (GO:0004897)
  • interleukin-6 receptor activity (GO:0004915)
  • interleukin-6 receptor activity (GO:0004915)
  • interleukin-11 receptor activity (GO:0004921)
  • leukemia inhibitory factor receptor activity (GO:0004923)
  • oncostatin-M receptor activity (GO:0004924)
  • receptor binding (GO:0005102)
  • ciliary neurotrophic factor receptor binding (GO:0005127)
  • protein homodimerization activity (GO:0042803)
  • interleukin-27 receptor activity (GO:0045509)
• Processes
  • positive regulation of acute inflammatory response (GO:0002675)
  • positive regulation of adaptive immune response (GO:0002821)
  • glycogen metabolic process (GO:0005977)
  • signal transduction (GO:0007165)
  • positive regulation of cell proliferation (GO:0008284)
  • regulation of Notch signaling pathway (GO:0008593)
  • positive regulation vascular endothelial growth factor production (GO:0010575)
  • positive regulation of cardiac muscle hypertrophy (GO:0010613)
  • response to cytokine stimulus (GO:0034097)
  • positive regulation of T cell proliferation (GO:0042102)
  • positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)
  • positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)
  • positive regulation of osteoblast differentiation (GO:0045669)
  • positive regulation of anti-apoptosis (GO:0045768)
  • leukemia inhibitory factor signaling pathway (GO:0048861)
  • interleukin-27-mediated signaling pathway (GO:0070106)
  • ciliary neurotrophic factor-mediated signaling pathway (GO:0070120)
• Components
  • extracellular region (GO:0005576)
  • plasma membrane (GO:0005886)
  • interleukin-6 receptor complex (GO:0005896)
  • oncostatin-M receptor complex (GO:0005900)
  • external side of plasma membrane (GO:0009897)
  • integral to membrane (GO:0016021)
  • ciliary neurotrophic factor receptor complex (GO:0070110)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
IL6ST	STAT3	Invivo	Novotny-Diermayr V et al.	12361954
IL6ST	CNTF	Invivo	Schuster B et al.	12643274
IL6ST	CNTFR	Invitro	Plun-Favreau H et al.	11285233
IL6ST	HCK	Invivo	Schaeffer M et al.	11689697
JAK1	IL6ST	Invivo	Haan C et al.	11468294
JAK1	IL6ST	Invivo	Haan C et al.	11742534
JAK1	IL6ST	Invitro	Haan C et al.	11468294
JAK1	IL6ST	Invitro	Haan C et al.	11742534
IL6R	IL6ST	Invitro	Taga T et al.	2788034
IL6ST	LIFR	Invivo	Timmermann A et al.	12047380
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources