Gene: ITIH4

official authority: ITIH4, inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

• Synonyms: DKFZp686G21125; H4P; IHRP; ITIHL1; PK120
• Other Designations: inter-alpha (globulin) inhibitor H4; plasma kallikrein-sensitive glycoprotein
• Description: inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
• Type: protein-coding
• Chromosome: 3
• Organism: Homo sapiens
• Omim: 600564
  
• title:Inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein);
• tissue expression: bladder; blood; brain; connective tissue; ear; embryonic tissue; eye; liver; lung; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; placenta; prostate; testis; thymus; trachea; uterus; breast (mammary gland) tumor; germ cell tumor; head and neck tumor; leukemia; liver tumor; lymphoma; non-neoplasia; normal; ovarian tumor; soft tissue/muscle tissue tumor; uterine tumor; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Grade 1(2) vs 3	---	cDNA Microarray	---	10963602

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000003.11	NM_002218.3	NP_002209.2	Q14624	---

Gene Expression Data

• genes highly correlated to ITIH4 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: ITIH4_HUMAN

• Description: Flags: Precursor;
• Length: 930 aa
• Function: May be involved in acute phase reactions. Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14624-1; Sequence=Displayed; Name=2; IsoId=Q14624-2; Sequence=VSP_002761, VSP_002762; Note=No experimental confirmation available;
• Location: Secreted.

InterPro domains

• Inter-alpha-trypsin inhibitor heavy chain, C-terminal (IPR010600)
• Vault protein inter-alpha-trypsin (IPR013694)
• Vault protein inter-alpha-trypsin, metazoa (IPR006587)
• von Willebrand factor, type A (IPR002035)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • serine-type endopeptidase inhibitor activity (GO:0004867)
• Processes
  • acute-phase response (GO:0006953)
  • hyaluronan metabolic process (GO:0030212)
• Components
  • extracellular region (GO:0005576)
  • nucleus (GO:0005634)
  • cytoplasm (GO:0005737)
  • cytoskeleton (GO:0005856)

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Note: data printed here are integrated from public resources