Gene: KIF2A

official authority: KIF2A, kinesin heavy chain member 2A

• Synonyms: HK2; KIF2
• Other Designations: Kinesin, heavy chain, 2; kinesin heavy chain member 2
• Description: kinesin heavy chain member 2A
• Type: protein-coding
• Chromosome: 5
• Organism: Homo sapiens
• Omim: 602591
  
• title:Kinesin heavy chain member 2A;
• tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; muscle; nerve; pancreas; parathyroid; pharynx; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; non-neoplasia; normal; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000005.9	NM_001098511.1	NP_001091981.1	O00139	2GRY
NC_000005.9	NM_004520.3	NP_004511.2	O00139	2GRY

Gene Expression Data

• genes highly correlated to KIF2A in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: KIF2A_HUMAN

• Description: AltName: Full=HK2;
• Length: 706 aa
• Function: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. similarity). Event=Alternative splicing; Named isoforms=4; Name=3; IsoId=O00139-3; Sequence=Displayed; Name=1; Synonyms=HK2; IsoId=O00139-1; Sequence=VSP_028374; Name=2; Synonyms=HK2s; IsoId=O00139-2; Sequence=VSP_028374, VSP_028375; Name=4; IsoId=O00139-4; Sequence=VSP_028376; Note=Phosphorylated on Ser-579 (By similarity). No experimental confirmation available;
• Location: Cytoplasm (By similarity). Centrosome (By similarity).

InterPro domains

• Kinesin, motor region (IPR001752)
• Kinesin, motor region, conserved site (IPR019821)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Cell Cycle, Mitotic (Reactome)

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • microtubule motor activity (GO:0003777)
  • ATP binding (GO:0005524)
• Processes
  • microtubule-based movement (GO:0007018)
  • multicellular organismal development (GO:0007275)
  • nervous system development (GO:0007399)
  • cell differentiation (GO:0030154)
• Components
  • cytoplasm (GO:0005737)
  • centrosome (GO:0005813)
  • microtubule (GO:0005874)

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Note: data printed here are integrated from public resources