Gene: LAMA4

official authority: LAMA4, laminin, alpha 4

• Synonyms: DKFZp686D23145; LAMA3; LAMA4*-1
• Other Designations: OTTHUMP00000017039; OTTHUMP00000017043; laminin alpha 4 chain
• Description: laminin, alpha 4
• Type: protein-coding
• Chromosome: 6
• Organism: Homo sapiens
• Omim: 600133
  
• title:Laminin, alpha 4;
• tissue expression: adipose tissue; adrenal gland; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; liver; lung; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000006.11	NM_001105206.1	NP_001098676.1	Q16363	---
NC_000006.11	NM_001105207.1	NP_001098677.1	Q5D044	---
NC_000006.11	NM_001105208.1	NP_001098678.1	Q9BTB8	---
NC_000006.11	NM_001105209.1	NP_001098679.1	Q5D044	---
NC_000006.11	NM_002290.3	NP_002281.2	Q16363	---

Gene Expression Data

• genes highly correlated to LAMA4 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: LAMA4_HUMAN

• Description: Flags: Precursor;
• Length: 1823 aa
• Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
• Location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

InterPro domains

• Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
• EGF-like region, conserved site (IPR013032)
• EGF-like, laminin (IPR002049)
• Laminin G (IPR001791)
• Laminin G, subdomain 2 (IPR012680)
• Laminin I (IPR009254)
• Laminin II (IPR010307)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Focal adhesion (KEGG map) (KEGG ontology)
• ECM-receptor interaction (KEGG map) (KEGG ontology)
• Pathways in cancer (KEGG map) (KEGG ontology)
• Small cell lung cancer (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • receptor binding (GO:0005102)
  • extracellular matrix structural constituent (GO:0005201)
• Processes
  • regulation of cell adhesion (GO:0030155)
  • regulation of cell migration (GO:0030334)
  • regulation of embryonic development (GO:0045995)
• Components
  • extracellular region (GO:0005576)
  • basal lamina (GO:0005605)
  • laminin-1 complex (GO:0005606)
  • extracellular space (GO:0005615)

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Note: data printed here are integrated from public resources