Gene: MAPT

official authority: MAPT, microtubule-associated protein tau

• Synonyms: DDPAC; FLJ31424; FTDP-17; MAPTL; MGC138549; MSTD; MTBT1; MTBT2; PPND; TAU
• Other Designations: G protein beta1/gamma2 subunit-interacting factor 1; microtubule-associated protein tau, isoform 4
• Description: microtubule-associated protein tau
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 157140
  
• title:Microtubule-associated protein tau;
• tissue expression: bone; brain; cervix; connective tissue; ear; embryonic tissue; eye; intestine; kidney; lung; mammary gland; muscle; nerve; pancreas; parathyroid; placenta; prostate; salivary gland; testis; thyroid; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; germ cell tumor; glioma; head and neck tumor; kidney tumor; lung tumor; non-neoplasia; normal; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; soft tissue/muscle tissue tumor; uterine tumor; fetus; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Estrogen receptor positive vs negative	---	cDNA Microarray	---	11562467

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_001123066.2	NP_001116538.1	P10636	1I8H
NC_000017.10	NM_001123067.2	NP_001116539.1	P10636	1I8H
NC_000017.10	NM_005910.4	NP_005901.2	P10636	1I8H
NC_000017.10	NM_016834.3	NP_058518.1	P10636	1I8H
NC_000017.10	NM_016835.3	NP_058519.2	P10636	1I8H
NC_000017.10	NM_016841.3	NP_058525.1	P10636	1I8H

Gene Expression Data

• genes highly correlated to MAPT in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: TAU_HUMAN

• Description: Short=PHF-tau;
• Length: 758 aa
• Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
• Location: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

InterPro domains

• Microtubule associated protein Tau (IPR015562)
• Tau protein (IPR002955)
• Tubulin-binding Tau protein (IPR001084)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• MAPK signaling pathway (KEGG map) (KEGG ontology)
• Alzheimer's disease (KEGG map) (KEGG ontology)

• Apoptosis (Reactome)

Gene Ontology

• Functions
  • structural constituent of cytoskeleton (GO:0005200)
  • microtubule binding (GO:0008017)
  • microtubule binding (GO:0008017)
  • lipoprotein binding (GO:0008034)
  • SH3 domain binding (GO:0017124)
  • enzyme binding (GO:0019899)
  • apolipoprotein E binding (GO:0034187)
  • identical protein binding (GO:0042802)
• Processes
  • microtubule cytoskeleton organization (GO:0000226)
  • microtubule cytoskeleton organization (GO:0000226)
  • negative regulation of microtubule depolymerization (GO:0007026)
  • positive regulation of microtubule polymerization (GO:0031116)
  • positive regulation of microtubule polymerization (GO:0031116)
  • positive regulation of axon extension (GO:0045773)
  • positive regulation of axon extension (GO:0045773)
  • generation of neurons (GO:0048699)
• Components
  • cytoplasm (GO:0005737)
  • cytosol (GO:0005829)
  • cytoskeleton (GO:0005856)
  • microtubule (GO:0005874)
  • microtubule associated complex (GO:0005875)
  • plasma membrane (GO:0005886)
  • plasma membrane (GO:0005886)
  • axon (GO:0030424)
  • axon (GO:0030424)
  • growth cone (GO:0030426)
  • growth cone (GO:0030426)
  • cell projection (GO:0042995)
  • tubulin complex (GO:0045298)
  • tubulin complex (GO:0045298)

Association with cell cycle

• gene entry: MAPT (from Cell Cycle Database)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
PSEN1	MAPT	Invivo	Takashima A et al.	9689133
APOE	MAPT	Invitro	Golombowski S et al.	9147408
APOE	MAPT	Invitro	Huang DY et al.	7566652
MAPT	CALM1	Invitro	Padilla R et al.	2123288
SPTB	MAPT	Invivo	Carlier MF et al.	6743699
YWHAZ	MAPT	Invivo	Hashiguchi M et al.	10840038
OGT	MAPT	Invitro	Okuyama R et al.	12911634
OGT	MAPT	Invitro	Arnold CS et al.	8910513
TUBB	MAPT	Invitro	Chau MF et al.	9922135
SNCA	MAPT	Invivo	Jensen PH et al.	10464279
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources