Gene: MYC

official authority: MYC, v-myc myelocytomatosis viral oncogene homolog (avian)

• Synonyms: MRTL; bHLHe39; c-Myc
• Other Designations: avian myelocytomatosis viral oncogene homolog; myc proto-oncogene protein; myc-related translation/localization regulatory factor; v-myc avian myelocytomatosis viral oncogene homolog
• Description: v-myc myelocytomatosis viral oncogene homolog (avian)
• Type: protein-coding
• Chromosome: 8
• Organism: Homo sapiens
• Omim: 190080
  
• title:;
• tissue expression: ;

Molecular alterations reported in literature

• DNA Amplification - Cell Line data

Type	Contig number	Fold	Cell line	Methods	Link to Pubmed
Amplification	42168268-42168269	5	BT20 - Human	Real time quantitative  Reverse Transcription PCR	10383126
Amplification	42168268-42168269	8	SK-BR-3 - Human	Real time quantitative  Reverse Transcription PCR	10383126

• DNA Amplification - Clinical data

Type	Contig number	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Amplification	42168268-42168269	6	F	---	Normal vs Invasive ductal carcinoma Invasive lobular carcinoma Lobular carcinoma in situ Ductal carcinoma in situ	---	Fluorescent in situ Hybridization Southern blot Polymerase Chain Reaction	9	12950019

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	F	---	Normal vs Carcinoma	---	Reverse transcription PCR	---	12532419

• Protein Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	F	---	Lymph node positive vs negative	---	Immunohistochemistry	---	11738392
Up	---	F	---	Normal vs Invasive Ductal Carcinoma Invasive Lobular Carcinoma	---	Western blot Densitometric analysis	41	11738392

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000008.10	NM_002467.4	NP_002458.2	P01106	1A93 1EE4 1MV0 1NKP 2A93

Gene Expression Data

• genes highly correlated to MYC in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: MYC_HUMAN

• Description: AltName: Full=Transcription factor p64;
• Length: 439 aa
• Function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
• Location: Nucleus.

InterPro domains

• Basic helix-loop-helix dimerisation region bHLH (IPR001092)
• Helix-loop-helix DNA-binding (IPR011598)
• Leucine zipper, Myc (IPR003327)
• Transcription regulator Myc (IPR002418)
• Transcription regulator Myc, N-terminal (IPR012682)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• MAPK signaling pathway (KEGG map) (KEGG ontology)
• ErbB signaling pathway (KEGG map) (KEGG ontology)
• Cell cycle (KEGG map) (KEGG ontology)
• Wnt signaling pathway (KEGG map) (KEGG ontology)
• TGF-beta signaling pathway (KEGG map) (KEGG ontology)
• Jak-STAT signaling pathway (KEGG map) (KEGG ontology)
• Pathways in cancer (KEGG map) (KEGG ontology)
• Colorectal cancer (KEGG map) (KEGG ontology)
• Endometrial cancer (KEGG map) (KEGG ontology)
• Thyroid cancer (KEGG map) (KEGG ontology)
• Bladder cancer (KEGG map) (KEGG ontology)
• Chronic myeloid leukemia (KEGG map) (KEGG ontology)
• Acute myeloid leukemia (KEGG map) (KEGG ontology)
• Small cell lung cancer (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • double-stranded DNA binding (GO:0003690)
  • transcription factor activity (GO:0003700)
  • protein binding (GO:0005515)
  • sequence-specific DNA binding (GO:0043565)
• Processes
  • release of cytochrome c from mitochondria (GO:0001836)
  • positive regulation of B cell apoptosis (GO:0002904)
  • glucose metabolic process (GO:0006006)
  • DNA fragmentation involved in apoptosis (GO:0006309)
  • transcription initiation (GO:0006352)
  • cellular iron ion homeostasis (GO:0006879)
  • activation of caspase activity (GO:0006919)
  • cell cycle arrest (GO:0007050)
  • regulation of mitotic cell cycle (GO:0007346)
  • positive regulation of cell proliferation (GO:0008284)
  • induction of apoptosis by intracellular signals (GO:0008629)
  • activation of pro-apoptotic gene products (GO:0008633)
  • negative regulation of survival gene product expression (GO:0008634)
  • response to radiation (GO:0009314)
  • protein processing (GO:0016485)
  • regulation of telomere maintenance (GO:0032204)
  • middle ear morphogenesis (GO:0042474)
  • regulation of apoptosis (GO:0042981)
  • positive regulation of catalytic activity (GO:0043085)
  • response to alkaloid (GO:0043279)
  • pigmentation (GO:0043473)
  • positive regulation of transcription from RNA polymerase II promoter (GO:0045944)
  • skeletal system morphogenesis (GO:0048705)
  • detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)
• Components
  • nucleus (GO:0005634)
  • cytoplasm (GO:0005737)
  • spindle (GO:0005819)
  • nuclear body (GO:0016604)

Association with cell cycle

• gene entry: MYC (from Cell Cycle Database)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
BRCA1	MYC	Invivo	Wang Q et al.	9788437
BRCA1	MYC	Invitro	Wang Q et al.	9788437
BRCA1	MYC	Two-hybrid	Wang Q et al.	9788437
MYC	CEBPA	Invivo	Tinel M et al.	12873812
MYC	CEBPA	Invitro	Tinel M et al.	12873812
MYC	RBL1	Invivo	Beijersbergen RL et al.	8076603
MLH1	MYC	Invivo	Mac Partlin M et al.	12584560
MLH1	MYC	Invitro	Mac Partlin M et al.	12584560
MLH1	MYC	Two-hybrid	Mac Partlin M et al.	12584560
HSPCA	MYC	Invivo	Carystinos GD et al.	12644583
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources