Gene: MYO1C

official authority: MYO1C, myosin IC

• Synonyms: FLJ23903; MMI-beta; MMIb; NMI; myr2
• Other Designations: myosin-I beta; nuclear myosin I
• Description: myosin IC
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 606538
  
• title:Myosin IC;
• tissue expression: adipose tissue; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; tonsil; trachea; umbilical cord; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_001080779.1	NP_001074248.1	O00159	---
NC_000017.10	NM_001080950.1	NP_001074419.1	O00159	---
NC_000017.10	NM_033375.4	NP_203693.3	O00159	---

Gene Expression Data

• genes highly correlated to MYO1C in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: MYO1C_HUMAN

• Description: Short=MMIb;
• Length: 1063 aa
• Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).
• Location: Cytoplasm. Cell membrane (By similarity). Cell projection, stereocilium membrane (By similarity). Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 in actin-based membranes. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.

InterPro domains

• IQ calmodulin-binding region (IPR000048)
• Myosin head, motor region (IPR001609)
• Myosin tail 2 (IPR010926)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • motor activity (GO:0003774)
  • actin binding (GO:0003779)
  • calmodulin binding (GO:0005516)
  • ATP binding (GO:0005524)
  • protein C-terminus binding (GO:0008022)
• Processes
  • protein transport (GO:0015031)
  • mRNA transport (GO:0051028)
  • intracellular protein transmembrane transport (GO:0065002)
• Components
  • stress fiber (GO:0001725)
  • nucleus (GO:0005634)
  • nuclear pore (GO:0005643)
  • nucleoplasm (GO:0005654)
  • nucleolus (GO:0005730)
  • cytoplasm (GO:0005737)
  • plasma membrane (GO:0005886)
  • brush border (GO:0005903)
  • basal plasma membrane (GO:0009925)
  • lateral plasma membrane (GO:0016328)
  • filamentous actin (GO:0031941)
  • myosin I complex (GO:0045160)
  • stereocilium membrane (GO:0060171)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
MYO1C	CBL	Two-hybrid	Robertson H et al.	9367879
WDR39	MYO1C	Affinity Capture-MS	Ewing RM et al.	17353931
NEK6	MYO1C	Affinity Capture-MS	Ewing RM et al.	17353931
RGS19IP1	MYO1C	Affinity Capture-MS	Ewing RM et al.	17353931
WDR8	MYO1C	Affinity Capture-MS	Ewing RM et al.	17353931

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources