Gene: NCF2

official authority: NCF2, neutrophil cytosolic factor 2

• Synonyms: FLJ93058; NCF-2; NOXA2; P67-PHOX; P67PHOX
• Other Designations: 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; OTTHUMP00000033269; OTTHUMP00000033270; chronic granulomatous disease, autosomal 2; neutrophil cytosol factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
• Description: neutrophil cytosolic factor 2
• Type: protein-coding
• Chromosome: 1
• Organism: Homo sapiens
• Omim: 608515
  
• title:Neutrophil cytosolic factor 2;
• tissue expression: blood; bone; bone marrow; brain; cervix; connective tissue; esophagus; eye; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; ovary; pancreas; pharynx; placenta; skin; spleen; testis; thymus; thyroid; trachea; uterus; vascular; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; esophageal tumor; germ cell tumor; glioma; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; skin tumor; uterine tumor; fetus; neonate; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860
Down	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000001.10	NM_000433.3	NP_000424.2	P19878	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
NC_000001.10	NM_001127651.1	NP_001121123.1	P19878	1E96 1HH8 1K4U 1OEY 1WM5 2DMO

Gene Expression Data

• genes highly correlated to NCF2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: NCF2_HUMAN

• Description: AltName: Full=p67-phox;
• Length: 526 aa
• Function: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
• Location: Cytoplasm.

InterPro domains

• Neutrophil cytosol factor 2 (IPR000108)
• Octicosapeptide/Phox/Bem1p (IPR000270)
• Src homology-3 domain (IPR001452)
• Tetratricopeptide TPR-1 (IPR001440)
• Tetratricopeptide-like helical (IPR011990)
• Tetratricopeptide region (IPR013026)
• Tetratricopeptide repeat (IPR019734)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Leukocyte transendothelial migration (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • protein C-terminus binding (GO:0008022)
  • electron carrier activity (GO:0009055)
  • superoxide-generating NADPH oxidase activity (GO:0016175)
  • Rac GTPase binding (GO:0048365)
• Processes
  • cellular defense response (GO:0006968)
  • superoxide release (GO:0042554)
  • innate immune response (GO:0045087)
  • respiratory burst (GO:0045730)
• Components
  • acrosomal vesicle (GO:0001669)
  • nucleus (GO:0005634)
  • nucleolus (GO:0005730)
  • cytoplasm (GO:0005737)
  • NADPH oxidase complex (GO:0043020)

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Note: data printed here are integrated from public resources