Gene: NFKBIB
official authority: NFKBIB, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
- Synonyms: IKBB; TRIP9
- Other Designations: -
- Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
- Type: protein-coding
- Chromosome: 19
- Organism: Homo sapiens
- Omim: 604495
- title:Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta;
- tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; trachea; uterus; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;
Molecular alterations reported in literature
Gene products
| genomic | RNA | protein | Uniprot accession | PDB Structure |
| NC_000019.9 | NM_001001716.1 | NP_001001716.1 | Q15653 | --- |
| NC_000019.9 | NM_002503.3 | NP_002494.2 | Q15653 | --- |
Gene Expression Data
- genes highly correlated to NFKBIB in a primary tumour dataset
- Differential Gene Expression
- Gene Expression Atlas
Interacting miRNA
- view miRNA list
Protein: IKBB_HUMAN
- Description: Short=TRIP-9;
- Length: 356 aa
- Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
- Location: Cytoplasm (By similarity). Nucleus (By similarity).
InterPro domains
SNPs and Protein Structural Models
- view SNPs list and use modelling tool
Human Protein Atlas stained tissues
- Protein expression in breast cancer tissues
- show related stained tissue images
Pathways
- Chemokine signaling pathway (KEGG map) (KEGG ontology)
- NOD-like receptor signaling pathway (KEGG map) (KEGG ontology)
- RIG-I-like receptor signaling pathway (KEGG map) (KEGG ontology)
- Cytosolic DNA-sensing pathway (KEGG map) (KEGG ontology)
- T cell receptor signaling pathway (KEGG map) (KEGG ontology)
- B cell receptor signaling pathway (KEGG map) (KEGG ontology)
- Neurotrophin signaling pathway (KEGG map) (KEGG ontology)
- Adipocytokine signaling pathway (KEGG map) (KEGG ontology)
Signaling in Immune system (Reactome)
Gene Ontology
BioGrid interactions
| Interactant A | Interactant B | experiment | source | Pubmed ID |
| RELA | NFKBIB | Invivo | Suyang H et al. | 8816457 |
| RELA | NFKBIB | Invivo | Chen Y et al. | 12672800 |
| RELA | NFKBIB | Invitro | Suyang H et al. | 8816457 |
| RELA | NFKBIB | Invitro | Chen Y et al. | 12672800 |
| RXRA | NFKBIB | Invitro | Na SY et al. | 9452433 |
| RXRA | NFKBIB | Invitro | Lee JW et al. | 7776974 |
| RXRA | NFKBIB | Two-hybrid | Na SY et al. | 9452433 |
| RXRA | NFKBIB | Two-hybrid | Lee JW et al. | 7776974 |
| CHUK | NFKBIB | Invitro | DiDonato JA et al. | 9252186 |
| NFKBIB | BTRC | Invivo | Wu C et al. | 10514424 |
| view the complete list | ||||
Note: data printed here are integrated from public resources