Gene: NNMT

official authority: NNMT, nicotinamide N-methyltransferase

• Synonyms: -
• Other Designations: -
• Description: nicotinamide N-methyltransferase
• Type: protein-coding
• Chromosome: 11
• Organism: Homo sapiens
• Omim: 600008
  
• title:Nicotinamide N-methyltransferase;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pharynx; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; trachea; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	---	---	invasive (INV) breast ductal carcinoma and lymph node metastatic (MET) breast carcinoma vs. normal breast tissue	---	SAGE	---	15608061

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000011.9	NM_006169.2	NP_006160.1	P40261	2IIP

Gene Expression Data

• genes highly correlated to NNMT in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: NNMT_HUMAN

• Description: EC=2.1.1.1;
• Length: 264 aa
• Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
• Location: Cytoplasm.

InterPro domains

• Methyltransferase, NNMT/PNMT/TEMT (IPR000940)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Nicotinate and nicotinamide metabolism (KEGG map) (KEGG ontology)
• Metabolic pathways (KEGG map) (KEGG ontology)

• Biological oxidations (Reactome)

Gene Ontology

• Functions
  • nicotinamide N-methyltransferase activity (GO:0008112)
  • methyltransferase activity (GO:0008168)
  • transferase activity (GO:0016740)
• Components
  • cytoplasm (GO:0005737)

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Note: data printed here are integrated from public resources