Gene: PDE11A
official authority: PDE11A, phosphodiesterase 11A
- Synonyms: FLJ23693; MGC133355; MGC133356; PPNAD2
- Other Designations: cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cyclic nucleotide phosphodiesterase 11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
- Description: phosphodiesterase 11A
- Type: protein-coding
- Chromosome: 2
- Organism: Homo sapiens
- Omim: 604961
- title:Phosphodiesterase 11A;
- tissue expression: brain; larynx; mouth; muscle; nerve; parathyroid; prostate; testis; uterus; germ cell tumor; head and neck tumor; non-neoplasia; normal; fetus; juvenile; adult;
Molecular alterations reported in literature
Gene products
| genomic | RNA | protein | Uniprot accession | PDB Structure |
| NC_000002.11 | NM_001077196.1 | NP_001070664.1 | Q9HCR9 | --- |
| NC_000002.11 | NM_001077197.1 | NP_001070665.1 | Q9HCR9 | --- |
| NC_000002.11 | NM_001077358.1 | NP_001070826.1 | Q9HCR9 | --- |
| NC_000002.11 | NM_016953.3 | NP_058649.3 | Q9HCR9 | --- |
Gene Expression Data
- genes highly correlated to PDE11A in a primary tumour dataset
- Differential Gene Expression
- Gene Expression Atlas
Interacting miRNA
- view miRNA list
Protein: PDE11_HUMAN
- Description: AltName: Full=cAMP and cGMP phosphodiesterase 11A;
- Length: 934 aa
- Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively.
- Location: Cytoplasm, cytosol.
InterPro domains
- GAF (IPR003018)
- Metal-dependent phosphohydrolase, HD region (IPR003607)
- 3'5'-cyclic nucleotide phosphodiesterase (IPR002073)
SNPs and Protein Structural Models
- view SNPs list and use modelling tool
Human Protein Atlas stained tissues
- Protein expression in breast cancer tissues
- show related stained tissue images
Pathways
- Purine metabolism (KEGG map) (KEGG ontology)
Gene Ontology
Note: data printed here are integrated from public resources