Gene: CYB5R4

official authority: CYB5R4, cytochrome b5 reductase 4

• Synonyms: NCB5OR; RP4-676J13.1; dJ676J13.1
• Other Designations: NADPH cytochrome B5 oxidoreductase; cytochrome b-type NAD(P)H oxidoreductase; flavohemoprotein b5+b5R
• Description: cytochrome b5 reductase 4
• Type: protein-coding
• Chromosome: 6
• Organism: Homo sapiens
• Omim: 608343
  
• title:Cytochrome b5 reductase 4;
• tissue expression: bladder; blood; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; muscle; ovary; pancreas; parathyroid; placenta; prostate; skin; stomach; testis; thymus; thyroid; trachea; uterus; vascular; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; colorectal tumor; esophageal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; primitive neuroectodermal tumor of the CNS; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000006.11	NM_016230.3	NP_057314.2	Q7L1T6	---

Gene Expression Data

• genes highly correlated to CYB5R4 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: NB5R4_HUMAN

• Description: AltName: Full=N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein;
• Length: 521 aa
• Function: NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
• Location: Endoplasmic reticulum. Note=Soluble protein.

InterPro domains

• CS (IPR017447)
• CS domain (IPR007052)
• Cytochrome b5 (IPR001199)
• Cytochrome b5, heme-binding site (IPR018506)
• Ferredoxin reductase-type FAD-binding domain (IPR017927)
• NADH:cytochrome b5 reductase (CBR) (IPR001834)
• Oxidoreductase FAD-binding region (IPR008333)
• Oxidoreductase FAD/NAD(P)-binding (IPR001433)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • cytochrome-b5 reductase activity (GO:0004128)
  • electron carrier activity (GO:0009055)
  • NAD(P)H oxidase activity (GO:0016174)
  • NAD(P)H oxidase activity (GO:0016174)
  • oxidoreductase activity (GO:0016491)
  • heme binding (GO:0020037)
  • metal ion binding (GO:0046872)
• Processes
  • detection of oxygen (GO:0003032)
  • generation of precursor metabolites and energy (GO:0006091)
  • superoxide metabolic process (GO:0006801)
  • insulin secretion (GO:0030073)
  • glucose homeostasis (GO:0042593)
  • response to antibiotic (GO:0046677)
  • cell development (GO:0048468)
  • oxidation reduction (GO:0055114)
• Components
  • endoplasmic reticulum (GO:0005783)
  • perinuclear region of cytoplasm (GO:0048471)

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Note: data printed here are integrated from public resources