Gene: PRRX1

official authority: PRRX1, paired related homeobox 1

• Synonyms: PHOX1; PMX1; PRX1
• Other Designations: OTTHUMP00000033166; OTTHUMP00000033167; homeobox protein PHOX1; paired mesoderm homeo box 1; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b
• Description: paired related homeobox 1
• Type: protein-coding
• Chromosome: 1
• Organism: Homo sapiens
• Omim: 167420
  
• title:Paired related homeobox 1;
• tissue expression: bladder; bone; bone marrow; brain; connective tissue; ear; embryonic tissue; eye; heart; intestine; kidney; larynx; lung; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; pharynx; pituitary gland; placenta; prostate; skin; stomach; testis; trachea; uterus; vascular; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; lymphoma; non-neoplasia; normal; pancreatic tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000001.10	NM_006902.3	NP_008833.1	P54821	---
NC_000001.10	NM_022716.2	NP_073207.1	P54821	---

Gene Expression Data

• genes highly correlated to PRRX1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: PRRX1_HUMAN

• Description: AltName: Full=Homeobox protein PHOX1;
• Length: 245 aa
• Function: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). Event=Alternative splicing; Named isoforms=2; Name=PMX1-B; IsoId=P54821-1; Sequence=Displayed; Name=PMX1-A; IsoId=P54821-2; Sequence=VSP_002278;
• Location: Nucleus.

InterPro domains

• Paired-like homeodomain protein, OAR (IPR003654)
• Homeobox (IPR001356)
• Homeobox, conserved site (IPR017970)
• Homeodomain-related (IPR012287)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • transcription factor activity (GO:0003700)
  • transcription coactivator activity (GO:0003713)
  • sequence-specific DNA binding (GO:0043565)
• Processes
  • regulation of transcription, DNA-dependent (GO:0006355)
  • multicellular organismal development (GO:0007275)
• Components
  • nucleus (GO:0005634)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
PRRX1	GTF2I	Invitro	Grueneberg DA et al.	9334314
PRRX1	GTF2I	Invivo	Grueneberg DA et al.	9334314
MAFG	PRRX1	Invivo	Kataoka K et al.	11036080
MAFG	PRRX1	Invitro	Kataoka K et al.	11036080
PRRX1	SRF	Invitro	Grueneberg DA et al.	9334314
PRRX1	SRF	Invivo	Grueneberg DA et al.	9334314
MAFF	PRRX1	Invitro	Kataoka K et al.	11036080

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources