Gene: STEAP3

official authority: STEAP3, STEAP family member 3

• Synonyms: STMP3; TSAP6; dudlin-2
• Other Designations: 1010001D01Rik; OTTHUMP00000162092; OTTHUMP00000162093; dudlin 2; dudulin 2; six transmembrane prostate protein 3; tumor suppressor pHyde
• Description: STEAP family member 3
• Type: protein-coding
• Chromosome: 2
• Organism: Homo sapiens
• Omim: 609671
  
• title:STEAP family member 3;
• tissue expression: adipose tissue; ascites; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; mammary gland; mouth; muscle; nerve; pancreas; parathyroid; pituitary gland; placenta; prostate; skin; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; non-neoplasia; normal; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; uterine tumor; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000002.11	NM_001008410.1	NP_001008410.1	Q658P3	2VNS 2VQ3
NC_000002.11	NM_018234.2	NP_060704.2	Q658P3	2VNS 2VQ3
NC_000002.11	NM_182915.2	NP_878919.2	A8K6E3	---

Gene Expression Data

• genes highly correlated to STEAP3 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: STEA3_HUMAN

• Description: AltName: Full=Dudulin-2;
• Length: 488 aa
• Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
• Location: Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

InterPro domains

• Ferric reductase-like transmembrane component, N-terminal (IPR013130)
• NAD(P)-binding domain (IPR016040)
• NADP oxidoreductase, coenzyme F420-dependent (IPR004455)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• p53 signaling pathway (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • binding (GO:0005488)
  • iron ion binding (GO:0005506)
  • copper ion binding (GO:0005507)
  • electron carrier activity (GO:0009055)
  • oxidoreductase activity (GO:0016491)
  • metal ion binding (GO:0046872)
  • FAD binding (GO:0050660)
• Processes
  • ion transport (GO:0006811)
  • iron ion transport (GO:0006826)
  • apoptosis (GO:0006915)
  • cell cycle (GO:0007049)
  • oxidation reduction (GO:0055114)
• Components
  • endosome (GO:0005768)
  • endosome membrane (GO:0010008)
  • membrane (GO:0016020)
  • integral to membrane (GO:0016021)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
PKMYT1	TSAP6	Invivo	Passer BJ et al.	12606722
PKMYT1	TSAP6	Invitro	Passer BJ et al.	12606722
PKMYT1	TSAP6	Two-hybrid	Passer BJ et al.	12606722
BNIP3L	TSAP6	Invivo	Passer BJ et al.	12606722
BNIP3L	TSAP6	Invitro	Passer BJ et al.	12606722
BNIP3L	TSAP6	Two-hybrid	Passer BJ et al.	12606722

Show common annotations on gene first neighborhood in the protein-protein interaction network

---

Note: data printed here are integrated from public resources