Gene: PRKAR2B

official authority: PRKAR2B, protein kinase, cAMP-dependent, regulatory, type II, beta

• Synonyms: PRKAR2; RII-BETA
• Other Designations: H_RG363E19.2; WUGSC:H_RG363E19.2; cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase, regulatory subunit beta 2
• Description: protein kinase, cAMP-dependent, regulatory, type II, beta
• Type: protein-coding
• Chromosome: 7
• Organism: Homo sapiens
• Omim: 176912
  
• title:Protein kinase, cAMP-dependent, regulatory, type II, beta;
• tissue expression: adipose tissue; adrenal gland; blood; bone; bone marrow; brain; embryonic tissue; eye; heart; intestine; kidney; larynx; lung; lymph; lymph node; mammary gland; nerve; ovary; pancreas; parathyroid; pituitary gland; placenta; prostate; salivary gland; skin; stomach; testis; trachea; umbilical cord; vascular; adrenal tumor; breast (mammary gland) tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; lymphoma; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA Microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000007.13	NM_002736.2	NP_002727.2	P31323	---

Gene Expression Data

• genes highly correlated to PRKAR2B in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: KAP3_HUMAN

• Description: RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit;
• Length: 418 aa
• Function: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
• Location:

InterPro domains

• cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta (IPR003117)
• cAMP/cGMP-dependent protein kinase (IPR002373)
• Cyclic nucleotide-binding (IPR000595)
• Cyclic nucleotide-binding, conserved site (IPR018488)
• cAMP-dependent protein kinase regulatory subunit (IPR012198)
• RmlC-like jelly roll fold (IPR014710)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Apoptosis (KEGG map) (KEGG ontology)
• Insulin signaling pathway (KEGG map) (KEGG ontology)

• Cell Cycle, Mitotic (Reactome)

• Integration of energy metabolism (Reactome)

• Opioid Signalling (Reactome)

• Signalling by NGF (Reactome)

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • cAMP-dependent protein kinase regulator activity (GO:0008603)
  • cAMP binding (GO:0030552)
• Processes
  • regulation of protein amino acid phosphorylation (GO:0001932)
  • fatty acid metabolic process (GO:0006631)
  • learning (GO:0007612)
  • hormone-mediated signaling (GO:0009755)
• Components
  • cytoplasm (GO:0005737)
  • mitochondrion (GO:0005739)
  • Golgi apparatus (GO:0005794)
  • centrosome (GO:0005813)
  • cAMP-dependent protein kinase complex (GO:0005952)

Association with cell cycle

• gene entry: PRKAR2B (from Cell Cycle Database)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
PRKAR2B	C3orf15	Invivo	Yukitake H et al.	12223483
PRKAR2B	C3orf15	Invitro	Yukitake H et al.	12223483
NBEA	PRKAR2B	Invitro	Wang X et al.	11102458
NBEA	PRKAR2B	Invivo	Wang X et al.	11102458
AKAP10	PRKAR2B	Invitro	Huang LJ et al.	9326583
AKAP14	PRKAR2B	Invivo	Kultgen PL et al.	12475942
AKAP14	PRKAR2B	Invitro	Kultgen PL et al.	12475942
AKAP9	PRKAR2B	Invivo	Marx SO et al.	11799244
AKAP9	PRKAR2B	Invitro	Marx SO et al.	11799244
AKAP5	PRKAR2B	Invitro	Glantz SB et al.	8509414
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources