Gene: CRTAM

official authority: CRTAM, cytotoxic and regulatory T cell molecule

• Synonyms: -
• Other Designations: class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule
• Description: cytotoxic and regulatory T cell molecule
• Type: protein-coding
• Chromosome: 11
• Organism: Homo sapiens
• Omim: 612597
  
• title:Cytotoxic and regulatory T cell molecule;
• tissue expression: blood; brain; connective tissue; kidney; lung; mammary gland; muscle; spleen; thymus; breast (mammary gland) tumor; normal; soft tissue/muscle tissue tumor; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000011.9	NM_019604.2	NP_062550.2	O95727	---

Gene Expression Data

• genes highly correlated to CRTAM in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: CRTAM_HUMAN

• Description: Flags: Precursor;
• Length: 393 aa
• Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
• Location: Membrane; Single-pass type I membrane protein (Potential).

InterPro domains

• CD80-like, immunoglobulin C2-set (IPR013162)
• Immunoglobulin-like (IPR007110)
• Immunoglobulin-like fold (IPR013783)
• Immunoglobulin subtype (IPR003599)
• Immunoglobulin V-set (IPR013106)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Signaling in Immune system (Reactome)

Gene Ontology

• Functions
  • receptor binding (GO:0005102)
• Processes
  • T cell mediated cytotoxicity (GO:0001913)
  • detection of tumor cell (GO:0002355)
  • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002860)
  • immune response (GO:0006955)
  • cell recognition (GO:0008037)
  • positive regulation of cytokine secretion (GO:0050715)
  • activated T cell proliferation (GO:0050798)
  • detection of stimulus (GO:0051606)
• Components
  • plasma membrane (GO:0005886)
  • integral to membrane (GO:0016021)

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Note: data printed here are integrated from public resources