Gene: SH3GLB2

official authority: SH3GLB2, SH3-domain GRB2-like endophilin B2

• Synonyms: KIAA1848; PP6569; PP9455
• Other Designations: OTTHUMP00000022319; OTTHUMP00000022320; SH3-containing protein SH3GLB2
• Description: SH3-domain GRB2-like endophilin B2
• Type: protein-coding
• Chromosome: 9
• Organism: Homo sapiens
• Omim: 609288
  
• title:SH3-domain GRB2-like endophilin B2;
• tissue expression: ascites; bladder; blood; bone; brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; muscle; nerve; ovary; pancreas; parathyroid; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; uterus; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; infant; juvenile; adult;

Molecular alterations reported in literature

Gene Expression Data

• genes highly correlated to SH3GLB2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: SHLB2_HUMAN

• Description: AltName: Full=SH3 domain-containing GRB2-like protein B2;
• Length: 395 aa
• Function:
• Location: Cytoplasm.

InterPro domains

• BAR (IPR004148)
• Src homology-3 domain (IPR001452)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Endocytosis (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • protein binding (GO:0005515)
• Components
  • cytoplasm (GO:0005737)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
SH3GLB1	SH3GLB2	Invivo	Pierrat B et al.	11161816
SH3GLB1	SH3GLB2	Invitro	Pierrat B et al.	11161816
SH3GLB1	SH3GLB2	Two-hybrid	Pierrat B et al.	11161816
SH3GLB2	SH3GLB1	Invivo	Pierrat B et al.	11161816
SH3GLB2	SH3GLB1	Invitro	Pierrat B et al.	11161816
SH3GLB2	SH3GLB1	Two-hybrid	Pierrat B et al.	11161816
MAGEA1	SH3GLB2	Two-hybrid	Rual JF et al.	16189514
SH3GLB2	FLJ25770	Two-hybrid	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources