Gene: ABCE1

official authority: ABCE1, ATP-binding cassette, sub-family E (OABP), member 1

• Synonyms: ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I
• Other Designations: ATP-binding cassette, sub-family E, member 1; RNase L inhibitor; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor
• Description: ATP-binding cassette, sub-family E (OABP), member 1
• Type: protein-coding
• Chromosome: 4
• Organism: Homo sapiens
• Omim: 601213
  
• title:ATP-binding cassette, sub-family E (OABP), member 1;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000004.11	NM_001040876.1	NP_001035809.1	P61221	---
NC_000004.11	NM_002940.2	NP_002931.2	P61221	---

Gene Expression Data

• genes highly correlated to ABCE1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: ABCE1_HUMAN

• Description: AltName: Full=HuHP68;
• Length: 599 aa
• Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
• Location: Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.

InterPro domains

• 4Fe-4S ferredoxin, iron-sulpur binding domain (IPR017896)
• 4Fe-4S ferredoxin, iron-sulphur binding, subgroup (IPR001450)
• 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (IPR017900)
• ABC transporter, ABCE (IPR013283)
• ABC transporter-like (IPR003439)
• ABC transporter, conserved site (IPR017871)
• ATPase, AAA+ type, core (IPR003593)
• Possible metal-binding region in RNase L inhibitor, RLI (IPR007209)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • nucleotide binding (GO:0000166)
  • ATP binding (GO:0005524)
  • ribonuclease inhibitor activity (GO:0008428)
  • electron carrier activity (GO:0009055)
  • ATPase activity (GO:0016887)
  • iron-sulfur cluster binding (GO:0051536)
• Processes
  • RNA catabolic process (GO:0006401)
  • response to virus (GO:0009615)
  • interspecies interaction between organisms (GO:0044419)
• Components
  • cytoplasm (GO:0005737)
  • mitochondrion (GO:0005739)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
RNASEL	ABCE1	Invitro	Bisbal C et al.	7539425

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources