Gene: RPLP1

official authority: RPLP1, ribosomal protein, large, P1

• Synonyms: FLJ27448; MGC5215; P1; RPP1
• Other Designations: 60S acidic ribosomal protein P1; acidic ribosomal phosphoprotein P1; ribosomal protein P1
• Description: ribosomal protein, large, P1
• Type: protein-coding
• Chromosome: 15
• Organism: Homo sapiens
• Omim: 180520
  
• title:Ribosomal protein, large, P1;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; tonsil; umbilical cord; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA microarray	---	11823860
Up	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860
Up	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000015.9	NM_001003.2	NP_000994.1	P05386	---
NC_000015.9	NM_213725.1	NP_998890.1	A6NIB2	---

Gene Expression Data

• genes highly correlated to RPLP1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: RLA1_HUMAN

• Description: RecName: Full=60S acidic ribosomal protein P1;
• Length: 114 aa
• Function: Plays an important role in the elongation step of protein synthesis.
• Location:

InterPro domains

• Ribosomal protein 60S (IPR001813)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Ribosome (KEGG map) (KEGG ontology)

• 3' -UTR-mediated translational regulation (Reactome)

• Gene Expression (Reactome)

• Influenza Infection (Reactome)

• Metabolism of proteins (Reactome)

Gene Ontology

• Functions
  • RNA binding (GO:0003723)
  • structural constituent of ribosome (GO:0003735)
  • protein binding (GO:0005515)
• Processes
  • translational elongation (GO:0006414)
  • translational elongation (GO:0006414)
• Components
  • intracellular (GO:0005622)
  • cytoplasm (GO:0005737)
  • cytosol (GO:0005829)
  • ribosome (GO:0005840)
  • cytosolic large ribosomal subunit (GO:0022625)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
RPLP1	PDCD4	Invitro	Kang MJ et al.	12054647
RPLP1	RPLP2	Two-hybrid	Tchorzewski M et al.	10856704
RPLP1	PDCD4	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

---

Note: data printed here are integrated from public resources