Gene: RPS18

official authority: RPS18, ribosomal protein S18

• Synonyms: D6S218E; HKE3; KE-3; KE3; MGC117351; MGC126835; MGC126837
• Other Designations: 40S ribosomal protein S18; OTTHUMP00000029059; rhabdomyosarcoma antigen MU-RMS-40.21
• Description: ribosomal protein S18
• Type: protein-coding
• Chromosome: 6
• Organism: Homo sapiens
• Omim: 180473
  
• title:Ribosomal protein S18;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; tonsil; umbilical cord; uterus; vascular; adrenal tumor; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860
Down	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000006.11	NM_022551.2	NP_072045.1	P62269	---

Gene Expression Data

• genes highly correlated to RPS18 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: RS18_HUMAN

• Description: Short=Ke3;
• Length: 152 aa
• Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By similarity).
• Location: Cytoplasm.

InterPro domains

• Ribosomal protein S13 (IPR001892)
• Ribosomal protein S13, conserved site (IPR018269)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Ribosome (KEGG map) (KEGG ontology)

• 3' -UTR-mediated translational regulation (Reactome)

• Gene Expression (Reactome)

• Influenza Infection (Reactome)

• Metabolism of proteins (Reactome)

Gene Ontology

• Functions
  • molecular_function (GO:0003674)
  • structural constituent of ribosome (GO:0003735)
  • rRNA binding (GO:0019843)
• Processes
  • translational elongation (GO:0006414)
• Components
  • intracellular (GO:0005622)
  • cytoplasm (GO:0005737)
  • cytosol (GO:0005829)
  • ribosome (GO:0005840)
  • cytosolic small ribosomal subunit (GO:0022627)

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Note: data printed here are integrated from public resources