Gene: BGN

official authority: BGN, biglycan

• Synonyms: DSPG1; PG-S1; PGI; SLRR1A
• Other Designations: OTTHUMP00000025928; biglycan proteoglycan; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; small leucine-rich protein 1A
• Description: biglycan
• Type: protein-coding
• Chromosome: X
• Organism: Homo sapiens
• Omim: 301870
  
• title:Biglycan;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; mammary gland; mouth; muscle; nerve; ovary; pancreas; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Up	---	F	---	Normal Fibroadenoma vs Invasive Ductal Carcinoma Invasive Lobular Carcinoma	---	cDNA Microarray	---	10963602

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000023.10	NM_001711.3	NP_001702.1	P21810	---

Gene Expression Data

• genes highly correlated to BGN in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: PGS1_HUMAN

• Description: Flags: Precursor;
• Length: 368 aa
• Function: May be involved in collagen fiber assembly (By similarity).
• Location: Secreted, extracellular space, extracellular matrix (By similarity).

InterPro domains

• Leucine-rich repeat (IPR001611)
• Leucine-rich repeat, cysteine-rich flanking region, N-terminal (IPR000372)
• Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan (IPR016352)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • extracellular matrix structural constituent (GO:0005201)
  • protein binding (GO:0005515)
• Processes
  • biological_process (GO:0008150)
• Components
  • extracellular region (GO:0005576)
  • proteinaceous extracellular matrix (GO:0005578)
  • extracellular space (GO:0005615)
  • cytoplasm (GO:0005737)
  • transport vesicle (GO:0030133)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
APP	BGN	Invitro	Snow AD et al.	7793988
BGN	APOB	Invitro	Flood C et al.	12070165
BGN	COL4A2	Invitro	Wiberg C et al.	11259413
BGN	COL2A1	Invitro	Fleischmajer R et al.	2059554
BGN	COL1A1	Invitro	Schonherr E et al.	7852349
BGN	COL1A2	Invitro	Schonherr E et al.	7852349
BGN	ELN	Invivo	Reinboth B et al.	11723132
BGN	MFAP2	Invivo	Reinboth B et al.	11723132
BGN	TGFB1	Invitro	Iozzo RV et al.	10383378
BGN	TGFB1	Invitro	Hildebrand A et al.	8093006
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources