Gene: CCL2

official authority: CCL2, chemokine (C-C motif) ligand 2

• Synonyms: GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; MGC9434; SCYA2; SMC-CF
• Other Designations: monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte secretory protein JE; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2
• Description: chemokine (C-C motif) ligand 2
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 158105
  
• title:Chemokine (C-C motif) ligand 2;
• tissue expression: adipose tissue; adrenal gland; bladder; blood; bone; bone marrow; brain; connective tissue; embryonic tissue; eye; heart; intestine; kidney; larynx; liver; lung; mammary gland; muscle; pancreas; parathyroid; pharynx; placenta; prostate; skin; stomach; testis; uterus; vascular; adrenal tumor; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; leukemia; liver tumor; lung tumor; normal; pancreatic tumor; fetus; neonate; infant; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	BRCA1 mutation positive vs BRCA2 mutation positive, Sporadic	---	cDNA microarray	---	11823860
Down	---	F	---	Lymphocytic infiltrate positive vs negative	---	cDNA microarray	---	11823860
Up	---	---	---	BRCA1 mutation positive, Sporadic vs BRCA2 mutation positive	---	cDNA Microarray	---	11207349
Up	---	F	---	Grade 1(2) vs 3	---	cDNA microarray	---	11823860
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA Microarray	---	11207349
Up	---	F	---	Sporadic vs BRCA1 mutation positive, BRCA2 mutation positive	---	cDNA microarray	---	11823860

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_002982.3	NP_002973.1	B2R4V3	---

Gene Expression Data

• genes highly correlated to CCL2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: CCL2_HUMAN

• Description: Flags: Precursor;
• Length: 99 aa
• Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
• Location: Secreted.

InterPro domains

• Small chemokine, C-C group, conserved site (IPR000827)
• Small chemokine, interleukin-8-like (IPR001811)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Cytokine-cytokine receptor interaction (KEGG map) (KEGG ontology)
• Chemokine signaling pathway (KEGG map) (KEGG ontology)
• NOD-like receptor signaling pathway (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • G-protein-coupled receptor binding (GO:0001664)
  • protein kinase activity (GO:0004672)
  • signal transducer activity (GO:0004871)
  • chemokine activity (GO:0008009)
  • CCR2 chemokine receptor binding (GO:0031727)
• Processes
  • positive regulation of endothelial cell proliferation (GO:0001938)
  • monocyte chemotaxis (GO:0002548)
  • protein amino acid phosphorylation (GO:0006468)
  • cellular calcium ion homeostasis (GO:0006874)
  • anti-apoptosis (GO:0006916)
  • chemotaxis (GO:0006935)
  • inflammatory response (GO:0006954)
  • humoral immune response (GO:0006959)
  • cell adhesion (GO:0007155)
  • transforming growth factor beta receptor signaling pathway (GO:0007179)
  • G-protein signaling, coupled to cyclic nucleotide second messenger (GO:0007187)
  • JAK-STAT cascade (GO:0007259)
  • response to bacterium (GO:0009617)
  • organ morphogenesis (GO:0009887)
  • viral genome replication (GO:0019079)
  • cytokine-mediated signaling pathway (GO:0019221)
  • vascular endothelial growth factor receptor signaling pathway (GO:0048010)
  • macrophage chemotaxis (GO:0048246)
• Components
  • extracellular region (GO:0005576)
  • extracellular space (GO:0005615)
  • cytoplasm (GO:0005737)
  • cell soma (GO:0043025)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
CSPG2	CCL2	Invitro	Hirose J et al.	11083865
CCL2	CCL2	Invivo	Zhang Y et al.	7651403
CCR10	CCL2	Invivo	Bonini JA et al.	9364936
CCBP2	CCL2	Invivo	Bonini JA et al.	9364936
CCBP2	CCL2	Invivo	Nibbs RJ et al.	9405404
CCR2	CCL2	Invivo	Hemmerich S et al.	10529171
CCR2	CCL2	Invivo	Monteclaro FS et al.	9287323
CCR2	CCL2	Invitro	Hemmerich S et al.	10529171
CCR2	CCL2	Invitro	Monteclaro FS et al.	9287323
CCL2	CCR5	Invivo	Blanpain C et al.	10477718
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources