Gene: CXCL6

official authority: CXCL6, chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

• Synonyms: CKA-3; GCP-2; GCP2; SCYB6
• Other Designations: Small inducible cytokine subfamily B (Cys-X-Cys), member b; small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)
• Description: chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
• Type: protein-coding
• Chromosome: 4
• Organism: Homo sapiens
• Omim: 138965
  
• title:Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2);
• tissue expression: adipose tissue; bladder; bone; connective tissue; eye; intestine; kidney; liver; lung; pancreas; placenta; prostate; spleen; uterus; vascular; chondrosarcoma; germ cell tumor; leukemia; liver tumor; non-neoplasia; normal; pancreatic tumor; uterine tumor; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	---	---	invasive (INV) breast ductal carcinoma and lymph node metastatic breast carcinoma vs. normal breast tissue	---	SAGE	---	15608061

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000004.11	NM_002993.3	NP_002984.1	P80162	---

Gene Expression Data

• genes highly correlated to CXCL6 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: CXCL6_HUMAN

• Description: Flags: Precursor;
• Length: 114 aa
• Function: Chemotactic for neutrophil granulocytes. family.
• Location: Secreted.

InterPro domains

• Small chemokine, C-X-C/Interleukin 8 (IPR002473)
• Small chemokine, interleukin-8-like (IPR001811)
• Small chemokine, C-X-C (IPR001089)
• Small chemokine, C-X-C, conserved site (IPR018048)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Cytokine-cytokine receptor interaction (KEGG map) (KEGG ontology)
• Chemokine signaling pathway (KEGG map) (KEGG ontology)

• Signaling by GPCR (Reactome)

Gene Ontology

• Functions
  • chemokine activity (GO:0008009)
  • heparin binding (GO:0008201)
• Processes
  • chemotaxis (GO:0006935)
  • inflammatory response (GO:0006954)
  • immune response (GO:0006955)
  • signal transduction (GO:0007165)
  • cell-cell signaling (GO:0007267)
• Components
  • extracellular region (GO:0005576)
  • extracellular space (GO:0005615)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
IL8RA	CXCL6	Invivo	Williams MA et al.	10593335
IL8RA	CXCL6	Invivo	Wuyts A et al.	9692902
IL8RB	CXCL6	Invivo	Williams MA et al.	10593335
IL8RB	CXCL6	Invivo	Wuyts A et al.	9692902
IL8RA	CXCL6	Affinity Capture-MS	Rual JF et al.	16189514
IL8RB	CXCL6	Affinity Capture-MS	Rual JF et al.	16189514

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources