Gene: SDHD

official authority: SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein

• Synonyms: CBT1; PGL; PGL1; SDH4
• Other Designations: succinate dehydrogenase complex, subunit D; succinate dehydrogenase ubiquinone cytochrome B small subunit
• Description: succinate dehydrogenase complex, subunit D, integral membrane protein
• Type: protein-coding
• Chromosome: 11
• Organism: Homo sapiens
• Omim: 602690
  
• title:Succinate dehydrogenase complex, subunit D, integral membrane protein;
• tissue expression: adipose tissue; adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; stomach; testis; thyroid; uterus; vascular; adrenal tumor; bladder carcinoma; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000011.9	NM_003002.2	NP_002993.1	O14521	---

Gene Expression Data

• genes highly correlated to SDHD in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: DHSD_HUMAN

• Description: Flags: Precursor;
• Length: 159 aa
• Function: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
• Location: Mitochondrion inner membrane; Multi-pass membrane protein.

InterPro domains

• Cytochrome b, succinate dehydrogenase small subunit, CybS (IPR007992)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Citrate cycle (TCA cycle) (KEGG map) (KEGG ontology)
• Oxidative phosphorylation (KEGG map) (KEGG ontology)
• Metabolic pathways (KEGG map) (KEGG ontology)
• Alzheimer's disease (KEGG map) (KEGG ontology)
• Parkinson's disease (KEGG map) (KEGG ontology)
• Huntington's disease (KEGG map) (KEGG ontology)

• Diabetes pathways (Reactome)

• Integration of energy metabolism (Reactome)

• Pyruvate metabolism and TCA cycle (Reactome)

Gene Ontology

• Functions
  • succinate dehydrogenase activity (GO:0000104)
  • electron carrier activity (GO:0009055)
  • heme binding (GO:0020037)
  • metal ion binding (GO:0046872)
• Processes
  • tricarboxylic acid cycle (GO:0006099)
  • transport (GO:0006810)
  • electron transport chain (GO:0022900)
• Components
  • mitochondrion (GO:0005739)
  • mitochondrial envelope (GO:0005740)
  • mitochondrial inner membrane (GO:0005743)
  • mitochondrial inner membrane (GO:0005743)
  • membrane (GO:0016020)
  • integral to membrane (GO:0016021)

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Note: data printed here are integrated from public resources