Gene: BMP7

official authority: BMP7, bone morphogenetic protein 7

• Synonyms: OP-1
• Other Designations: OTTHUMP00000031357; osteogenic protein 1
• Description: bone morphogenetic protein 7
• Type: protein-coding
• Chromosome: 20
• Organism: Homo sapiens
• Omim: 112267
  
• title:Bone morphogenetic protein 7;
• tissue expression: bone; brain; connective tissue; embryonic tissue; eye; heart; intestine; kidney; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; placenta; prostate; skin; testis; thymus; tonsil; trachea; uterus; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; blastocyst; fetus; juvenile; adult;

Molecular alterations reported in literature

• RNA Expression - Clinical data

Expression	Fold	Gender	Age	Cancer type	Ethnic group	Methods	Frequency	Link to Pubmed
Down	---	F	---	Invasive Lobular Carcinoma vs Invasive Ductal Carcinoma	---	cDNA Microarray	---	10963602
Up	---	F	---	Grade 1(2) vs 3	---	cDNA Microarray	---	10963602

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000020.10	NM_001719.2	NP_001710.1	A8K571	---

Gene Expression Data

• genes highly correlated to BMP7 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: BMP7_HUMAN

• Description: Flags: Precursor;
• Length: 431 aa
• Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
• Location: Secreted.

InterPro domains

• Transforming growth factor beta (IPR001839)
• Transforming growth factor beta, conserved site (IPR017948)
• Transforming growth factor beta (TGFb), N-terminal (IPR001111)
• Transforming growth factor-beta-related (IPR015615)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Cytokine-cytokine receptor interaction (KEGG map) (KEGG ontology)
• Hedgehog signaling pathway (KEGG map) (KEGG ontology)
• TGF-beta signaling pathway (KEGG map) (KEGG ontology)

Gene Ontology

• Functions
  • cytokine activity (GO:0005125)
  • protein binding (GO:0005515)
  • growth factor activity (GO:0008083)
  • heparin binding (GO:0008201)
• Processes
  • ossification (GO:0001503)
  • mesoderm formation (GO:0001707)
  • kidney development (GO:0001822)
  • epithelial to mesenchymal transition (GO:0001837)
  • axon guidance (GO:0007411)
  • salivary gland morphogenesis (GO:0007435)
  • negative regulation of cell proliferation (GO:0008285)
  • embryonic pattern specification (GO:0009880)
  • organ morphogenesis (GO:0009887)
  • positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)
  • positive regulation of bone mineralization (GO:0030501)
  • BMP signaling pathway (GO:0030509)
  • epithelial cell differentiation (GO:0030855)
  • growth (GO:0040007)
  • regulation of phosphorylation (GO:0042325)
  • odontogenesis of dentine-containing tooth (GO:0042475)
  • positive regulation of apoptosis (GO:0043065)
  • positive regulation of osteoblast differentiation (GO:0045669)
  • negative regulation of cell cycle (GO:0045786)
  • positive regulation of transcription (GO:0045941)
  • positive regulation of transcription from RNA polymerase II promoter (GO:0045944)
  • cell development (GO:0048468)
  • embryonic camera-type eye morphogenesis (GO:0048596)
  • anatomical structure formation involved in morphogenesis (GO:0048646)
  • branching morphogenesis of a tube (GO:0048754)
  • negative regulation of neurogenesis (GO:0050768)
  • cartilage development (GO:0051216)
• Components
  • extracellular region (GO:0005576)
  • extracellular space (GO:0005615)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
BMP7	ACVR1	Invivo	ten Dijke P et al.	8006002
BMP7	ACVR2A	Invivo	Macias-Silva M et al.	9748228
BMP7	ENG	Invitro	Barbara NP et al.	9872992
BMP7	NOG	Invitro	Groppe J et al.	12478285
ACVR2B	BMP7	Invivo	Macias-Silva M et al.	9748228
BMP7	NCOA3	Invivo	Liu F et al.	7791754
BMPR1B	BMP7	Invivo	Yamada N et al.	8605097
BMP7	BMPR2	Invivo	Liu F et al.	7791754
BMP7	BMPR2	Two-hybrid	Liu F et al.	7791754
BMPR1A	BMP7	Invivo	Liu F et al.	7791754
view the complete list

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources