Gene: LEFTY2

official authority: LEFTY2, left-right determination factor 2

• Synonyms: EBAF; LEFTA; LEFTYA; MGC46222; TGFB4
• Other Designations: OTTHUMP00000035570; endometrial bleeding associated factor; endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily); transforming growth factor, beta-4 (endometrial bleeding-associated factor; LEFTY A)
• Description: left-right determination factor 2
• Type: protein-coding
• Chromosome: 1
• Organism: Homo sapiens
• Omim: 601877
  
• title:Left-right determination factor 2;
• tissue expression: brain; cervix; connective tissue; embryonic tissue; eye; heart; intestine; kidney; lung; ovary; pituitary gland; placenta; testis; uterus; cervical tumor; colorectal tumor; germ cell tumor; kidney tumor; non-neoplasia; normal; retinoblastoma; soft tissue/muscle tissue tumor; uterine tumor; blastocyst; fetus; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000001.10	NM_003240.2	NP_003231.2	O00292	---

Gene Expression Data

• genes highly correlated to LEFTY2 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: LFTY2_HUMAN

• Description: Flags: Precursor;
• Length: 366 aa
• Function: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
• Location: Secreted.

InterPro domains

• Transforming growth factor beta (IPR001839)
• Transforming growth factor, beta 4 (IPR003942)
• Transforming growth factor beta, conserved site (IPR017948)
• Transforming growth factor beta (TGFb), N-terminal (IPR001111)
• Transforming growth factor-beta-related (IPR015615)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• TGF-beta signaling pathway (KEGG map) (KEGG ontology)

• Hemostasis (Reactome)

Gene Ontology

• Functions
  • cytokine activity (GO:0005125)
  • transforming growth factor beta receptor binding (GO:0005160)
  • growth factor activity (GO:0008083)
• Processes
  • transforming growth factor beta receptor signaling pathway (GO:0007179)
  • multicellular organismal development (GO:0007275)
  • oocyte axis specification (GO:0007309)
  • cell growth (GO:0016049)
• Components
  • extracellular region (GO:0005576)
  • extracellular region (GO:0005576)
  • extracellular space (GO:0005615)
  • platelet alpha granule lumen (GO:0031093)

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Note: data printed here are integrated from public resources