Gene: TGM2
official authority: TGM2, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
- Synonyms: G-ALPHA-h; GNAH; TG2; TGC
- Other Designations: C polypeptide; OTTHUMP00000030960; TGase C; TGase-H; protein-glutamine-gamma-glutamyltransferase; tissue transglutaminase; transglutaminase 2; transglutaminase C
- Description: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
- Type: protein-coding
- Chromosome: 20
- Organism: Homo sapiens
- Omim: 190196
- title:Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase);
- tissue expression: adipose tissue; adrenal gland; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; liver; lung; lymph node; mammary gland; mouth; muscle; nerve; ovary; pancreas; parathyroid; pituitary gland; placenta; prostate; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; adrenal tumor; breast (mammary gland) tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; juvenile; adult;
Molecular alterations reported in literature
Gene products
| genomic | RNA | protein | Uniprot accession | PDB Structure |
| NC_000020.10 | NM_004613.2 | NP_004604.2 | P21980 | 1FAU 1KV3 2Q3Z |
| NC_000020.10 | NM_198951.1 | NP_945189.1 | P21980 | 1FAU 1KV3 2Q3Z |
Gene Expression Data
- genes highly correlated to TGM2 in a primary tumour dataset
- Differential Gene Expression
- Gene Expression Atlas
Interacting miRNA
- view miRNA list
Protein: TGM2_HUMAN
- Description: AltName: Full=TGase-H;
- Length: 687 aa
- Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
- Location:
InterPro domains
- Fibronectin, type III-like fold (IPR008957)
- Immunoglobulin-like fold (IPR013783)
- Transglutaminase-like (IPR002931)
- Transglutaminase, C-terminal (IPR008958)
- Transglutaminase, conserved site (IPR013808)
- Transglutaminase, N-terminal (IPR001102)
SNPs and Protein Structural Models
- view SNPs list and use modelling tool
Human Protein Atlas stained tissues
- Protein expression in breast cancer tissues
- show related stained tissue images
Pathways
- Huntington's disease (KEGG map) (KEGG ontology)
Gene Ontology
- Functions
- Processes
- blood vessel remodeling (GO:0001974)
- induction of apoptosis (GO:0006917)
- peptide cross-linking (GO:0018149)
- isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine (GO:0018153)
- positive regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043123)
- positive regulation of cell adhesion (GO:0045785)
- positive regulation of smooth muscle cell proliferation (GO:0048661)
- positive regulation of inflammatory response (GO:0050729)
- protein homooligomerization (GO:0051260)
- elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) (GO:0051482)
- Components
BioGrid interactions
| Interactant A | Interactant B | experiment | source | Pubmed ID |
| TGM2 | FN1 | Invitro | Heath DJ et al. | 11829448 |
| TGM2 | FN1 | Invitro | Akimov SS et al. | 11686302 |
| HD | TGM2 | Invivo | Chun W et al. | 11442349 |
| ANXA1 | TGM2 | Invitro | Ando Y et al. | 1670773 |
| TGM2 | RHOA | Invivo | Singh US et al. | 11350930 |
| TGM2 | RB1 | Invitro | Oliverio S et al. | 9315663 |
| SPARC | TGM2 | Invitro | Aeschlimann D et al. | 7730416 |
| PPHLN1 | TGM2 | Invitro | Kazerounian S et al. | 12853457 |
| TUBB | TGM2 | Invivo | Piredda L et al. | 9973324 |
| TUBB | TGM2 | Invitro | Piredda L et al. | 9973324 |
| view the complete list | ||||
Note: data printed here are integrated from public resources