Gene: TNFAIP1

official authority: TNFAIP1, tumor necrosis factor, alpha-induced protein 1 (endothelial)

• Synonyms: B12; B61; EDP1; MGC2317
• Other Designations: tumor necrosis factor, alpha-induced protein 1
• Description: tumor necrosis factor, alpha-induced protein 1 (endothelial)
• Type: protein-coding
• Chromosome: 17
• Organism: Homo sapiens
• Omim: 191161
  
• title:Tumor necrosis factor, alpha-induced protein 1 (endothelial);
• tissue expression: adrenal gland; ascites; bladder; blood; bone; bone marrow; brain; cervix; connective tissue; ear; embryonic tissue; esophagus; eye; heart; intestine; kidney; larynx; liver; lung; lymph; lymph node; mammary gland; mouth; muscle; ovary; pancreas; parathyroid; pharynx; pituitary gland; placenta; prostate; salivary gland; skin; spleen; stomach; testis; thymus; thyroid; trachea; umbilical cord; uterus; vascular; breast (mammary gland) tumor; cervical tumor; chondrosarcoma; colorectal tumor; esophageal tumor; gastrointestinal tumor; germ cell tumor; glioma; head and neck tumor; kidney tumor; leukemia; liver tumor; lung tumor; lymphoma; non-neoplasia; normal; ovarian tumor; pancreatic tumor; primitive neuroectodermal tumor of the CNS; prostate cancer; retinoblastoma; skin tumor; soft tissue/muscle tissue tumor; uterine tumor; embryoid body; blastocyst; fetus; neonate; infant; adult;

Molecular alterations reported in literature

Gene products

genomic	RNA	protein	Uniprot accession	PDB Structure
NC_000017.10	NM_021137.4	NP_066960.1	Q13829	---

Gene Expression Data

• genes highly correlated to TNFAIP1 in a primary tumour dataset
• Differential Gene Expression
• Gene Expression Atlas

Interacting miRNA

• view miRNA list

Protein: TNAP1_HUMAN

• Description: AltName: Full=Protein B12;
• Length: 316 aa
• Function: Enhances the PCNA-dependent DNA polymerase delta activity (By similarity).
• Location:

InterPro domains

• BTB/POZ-like (IPR000210)
• BTB/POZ fold (IPR011333)
• Potassium channel, voltage dependent, Kv, tetramerisation (IPR003131)

SNPs and Protein Structural Models

• view SNPs list and use modelling tool

Human Protein Atlas stained tissues

• Protein expression in breast cancer tissues
• show related stained tissue images

Pathways

• Pathways information not available

Gene Ontology

• Functions
  • molecular_function (GO:0003674)
  • voltage-gated potassium channel activity (GO:0005249)
  • protein binding (GO:0005515)
• Processes
  • DNA replication (GO:0006260)
  • potassium ion transport (GO:0006813)
  • immune response (GO:0006955)
  • embryonic development (GO:0009790)
• Components
  • cellular_component (GO:0005575)
  • voltage-gated potassium channel complex (GO:0008076)
  • membrane (GO:0016020)

BioGrid interactions

Interactant A	Interactant B	experiment	source	Pubmed ID
EPHA2	TNFAIP1	Invivo	Pandey A et al.	7536959

Show common annotations on gene first neighborhood in the protein-protein interaction network

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Note: data printed here are integrated from public resources